Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in ApcMin/+ mice
2002; Elsevier BV; Volume: 187; Issue: 1-2 Linguagem: Inglês
10.1016/s0304-3835(02)00402-0
ISSN1872-7980
AutoresJ. Tucker, Celestia Davis, Maria E. Kitchens, Marlene A. Bunni, David G. Priest, H. Trent Spencer, Franklin G. Berger,
Tópico(s)Metabolism, Diabetes, and Cancer
Resumo5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years. The ApcMin/+ mouse, which is genetically predisposed to intestinal neoplasia, was used to examine the effects of 5-FU in this system and the impact of dietary folic acid on those effects. 5-FU treatment resulted in a 60–80% reduction in tumor number. Clinically relevant toxicities, including myelosuppression and mucositis, are a part of this response. Tumor numbers rebounded completely following termination of 5-FU therapy, indicating that the drug inhibits tumor growth but does not eradicate them. In mice that were fed with a defined diet containing no folic acid (0 ppm), 5-FU not only induced regression of pre-existing tumors, but also inhibited tumor recovery following drug withdrawal. Our data indicate that a dietary folic acid deficiency, in promoting tumor regression and inhibiting tumor recovery, may enhance the therapeutic effects of 5-FU.
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