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Studies on the mechanism of carbon monoxide toxicity

1976; Elsevier BV; Volume: 20; Issue: 5 Linguagem: Inglês

10.1016/0022-4804(76)90125-6

1095-8673

T Orellano, E Dergal, Mohammed Alijani, Charles S. Briggs, Javier Vásquez, Leo R. Goldbaum, Karel B. Absolon,

Erythrocyte Function and Pathophysiology

Abstract Inhalation of 13% CO in dogs for 5 min was lethal in minutes to hours, hypothermia having only a minimal effect on survival. Even though the blood levels after CO inhalation were similar to those induced by transfusion of COHb red cells (64%, respectively, 60% COHb), no toxicity was observed in the latter. Intraperitoneal injections of 100% CO in amounts of up to 150 ml/kg of body weight daily for 90 days to a cummulative dose of 90 liters produced similar COHb blood levels and was nontoxic. Chronic intraperitoneal injection of CO presents a new model to study chronic effects of CO.