Is There a Blood-Brain Barrier at the Optic Nerve Head?
1975; American Medical Association; Volume: 93; Issue: 9 Linguagem: Inglês
10.1001/archopht.1975.01010020703008
ISSN1538-3601
AutoresM. O.M. Tso, C.-Y. Shih, I. W. McLean,
Tópico(s)Retinal Development and Disorders
ResumoThe retina and optic nerve have been demonstrated to possess a blood-brain barrier that prevents the passive passage of protein and certain dyes from the blood vessels into the extracellular space. Our observations suggest that an exception is present at the normal optic disc. Using horseradish peroxidase as a tracer for electron microscopy and the normal rhesus monkey as the experimental animal, we have demonstrated that in certain regions of the optic nerve head, horseradish peroxidase from the blood stream reaches the axons of the optic nerve through the border tissue of Elschnig from the adjacent choridal tissues. A barrier formed by a series of cell junctions between glial cells at the edge of the optic disc prevented spread of the tracer from the optic disc into the subretinal space.
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