O.117 Osteonecrosis of the jaw(s) associated with the use of bisphosphonates: An iatrogenic epidemic
2006; Elsevier BV; Volume: 34; Linguagem: Inglês
10.1016/s1010-5182(06)60146-7
ISSN1878-4119
AutoresJoseph Schoenaers, B. Moerenhout, Frank C. Combes,
Tópico(s)Boron Compounds in Chemistry
ResumoIntravenous bisphosphonates are widely used in the management of metastatic bone disease, as well as osteoporosis. Recent published reports have documented a possible link between treatment with intravenous bisphosphonates and osteonecrosis of the jaw. We report a case of osteonecrosis of the jaw in 1 patient with prostate cancer receiving both chemotherapy and intravenous zoledronic acid (Zometa). Bisphosphonates have been demonstrated to alter the normal bone microenvironment and appear to have direct effects on tumors as well. These changes may contribute to the development of osteonecrosis of the jaw, particularly after tooth extractions or other invasive dental procedures.
Referência(s)