Portal de Periódicos da CAPES

The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy

2007; Royal Society of Chemistry; Issue: 38 Linguagem: Inglês

10.1039/b709843j

1477-9234

Andrea Armstrong, John F. Valliant,

Bone health and treatments

The role of carboranes in medicinal chemistry has diversified in recent years and now extends into areas of drug discovery, molecular imaging, and targeted radionuclide therapy. An introduction to carborane chemistry is provided to familiarize the non-expert with some key properties of these molecules, followed by an overview of current medicinally-orientated research involving carboranes. The broad-ranging nature of this research is illustrated, with emphasis placed on recent highlights and advances in this field.