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An Analysis of the Composition of the Inflammatory Infiltrate in Autoimmune and Hepatitis B Virus-Induced Chronic Liver Disease

1983; Lippincott Williams & Wilkins; Volume: 3; Issue: 3 Linguagem: Inglês

10.1002/hep.1840030303

1527-3350

Luis F. Montaño, Fernando Aranguibel, Margarita Boffill, Alison H. Goodall, George Janossy, Howard C. Thomas,

Hepatitis B Virus Studies

The composition of the mononuclear cell infiltrate in the liver was studied in patients with autoimmune and hepatitis B virus (HBV)-induced liver disease. The ratio of inducer to cytotoxic/suppressor cells was greater in patients with lupoid chronic active liver disease, primary biliary cirrhosis, and HBeAb positive HBV-induced chronic active liver disease than in patients with HBeAg positive HBV-induced chronic hepatitis. In patients with chronic HBV-induced (HBeAb positive) liver disease, this ratio was greater in the periportal/portal area than in the lobule. These data are consistent with a relative deficiency of the cytotoxic/suppressor population of T cells in autoimmune liver diseases and possibly in HBeAb positive HBV-induced chronic active liver disease. In the latter patients, different ratios in the periportal and centrilobular zones suggest different mechanisms for periportal and lobular hepatitis.