Portal de Periódicos da CAPES

Calcium-induced lysozyme secretion from human polymorphonuclear leukocytes

1974; Elsevier BV; Volume: 60; Issue: 2 Linguagem: Inglês

10.1016/0006-291x(74)90312-x

1090-2104

Ira M. Goldstein, J. Horn, Howard B. Kaplan, Gerald Weissmann,

Enzyme Structure and Function

Calcium ions, in the absence of other stimuli, are capable of provoking the release by exocytosis of the granule-associated enzyme, lysozyme, from human polymorphonuclear leukocytes. Calcium-induced extrusion of lysozyme occurs in a concentration, time and temperature-dependent fashion. It is enhanced in the presence of extracellular inorganic phosphate and the ionophore, A-23187, and is not accompanied by the release from cells of cytoplasmic or lysosomal marker enzymes.