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A Specific Receptor for Retinol Binding Protein as Detected by the Binding of Human and Bovine Retinol Binding Protein to Pigment Epithelial Cells

1976; Elsevier BV; Volume: 81; Issue: 1 Linguagem: Inglês

10.1016/0002-9394(76)90198-7

1879-1891

J Heller, Dean Bok,

Retinal Development and Disorders

By means of autoradiographic techniques the specific plasma carrier of retinol, namely retinol binding protein (RBP) in a radioactive form (retinol-125I.RBP), bound specifically in vivo to the choroidal surface of intact, isolated bovine pigment epithelial cells. The retinol-125I.RBP did not bind to the retinal surface of the pigment epithelial cells nor did not bind to photoreceptors. Retinol is normally provided to the retina from the blood via a specific complex formation with a receptor on the chordial surface of the pigment epithelial cells. Retinol metabolism might be deranged in some diseases through a defect in the pigment epithelial receptor for RBP.