Portal de Periódicos da CAPES

Acrylonitriles, A New Group of Ultraviolet Absorbing Compounds**From the Departments of Dermatology and Pathology, Baylor University College of Medicine, Houston, Texas.

1962; Elsevier BV; Volume: 39; Issue: 5 Linguagem: Inglês

10.1038/jid.1962.138

1523-1747

ROBERT E. ROSSMAN, John M. Knox, Robert G. Freeman,

Skin Protection and Aging

Until suitable systemic means are available for protecting susceptible individuals from the cumulative damaging effects of excessive ultraviolet exposure, such protection will be limited to topically applied sunscreens. There are a great number of compounds with either physical or chemical properties which theoretically suggest their usefulness in this regard. The ultraviolet absorbing compound must dissipate the absorbed energy in a harmless manner. Sunscreens were first made available commercially in 1928, and since that time many have been introduced. The ideal sunscreen preparation, according to Keston, should be hypoallergenic, non-irritating, non-toxic, and stable (1). It should be cosmetically acceptable, reasonable in cost, and protect the skin from about ten times the amount of sunlight that causes perceptible erythema. For much of this country, with untanned skin the minimal erythema dose has been found to approximate twenty minutes of direct midday June sunlight (2). According to Daniels' calculations the M.E.D. for our area should be about 15 minutes under these conditions (3). Few of the commonly available sunscreens fulfill these criteria and no single preparation can be given blanket approval for universal use Investigative studies have been carried out in an effort to evaluate new ultraviolet absorbers as topical sunscreens. Many of these agents have originated in industry where they are widely used as stabilizers to protect fabrics, plastics, and other materials from photodegradation (4). A number have been tested and a few found worthy of more extensive evaluation. Early investigation by Knox, et al., and several years of clinical usage, have confirmed the effectiveness of the benzophenones (5—8). This group, along along with p-aminobenzoic acid as recommended by Rothman many years ago (9, 10), and a new family of compounds, the acrylonitriles, have * From the Departments of Dermatology and Pathology, Baylor University College of Medicine, Houston, Texas. Presented at the Twenty-third Annual Meeting of The Society for Investigative Dermatology, Inc., Chicago, Ill., June 27, 1962.