Synthesis of Indolines via a Domino Cu-Catalyzed Amidation/Cyclization Reaction
2008; American Chemical Society; Volume: 10; Issue: 13 Linguagem: Inglês
10.1021/ol8008792
ISSN1523-7060
AutoresAna Minatti, Stephen L. Buchwald,
Tópico(s)Chemical synthesis and alkaloids
ResumoA highly efficient one-pot procedure for the synthesis of indolines and their homologues based on a domino Cu-catalyzed amidation/nucleophilic substitution reaction has been developed. Substituted 2-iodophenethyl mesylates and related compounds afforded the corresponding products in excellent yields. No erosion of optical purity was observed when transforming enantiomerically pure mesylates under the reaction conditions.
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