PORPHYRIN‐BINDING PROTEINS IN SERUM*
1975; Wiley; Volume: 244; Issue: 1 Linguagem: Africâner
10.1111/j.1749-6632.1975.tb41558.x
ISSN1749-6632
AutoresUrsula Müller‐Eberhard, William T. Morgand̊,
Tópico(s)Neonatal Health and Biochemistry
ResumoAnnals of the New York Academy of SciencesVolume 244, Issue 1 p. 624-649 PORPHYRIN-BINDING PROTEINS IN SERUM* Ursula Muller-Eberhard, Ursula Muller-Eberhard Department of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, California 92037Search for more papers by this authorWilliam T. Morgand̊, William T. Morgand̊ Department of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, California 92037Search for more papers by this author Ursula Muller-Eberhard, Ursula Muller-Eberhard Department of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, California 92037Search for more papers by this authorWilliam T. Morgand̊, William T. Morgand̊ Department of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, California 92037Search for more papers by this author First published: April 1975 https://doi.org/10.1111/j.1749-6632.1975.tb41558.xCitations: 110 * This work was supported by the National Institutes of Health (Grants HD-04445, HE-08660, and AM-16737). † d̊ Recipient of a postdoctoral fellowship (AM-53050) from the National Institutes of Health. ‡ In this paper, the generic terms albumin and hemopexin will be used to denote these proteins without regard to the species. The source will be named only in instances in which the property to be discussed was shown for only one species, or when the property is species-specific. The terms serum and plasma are used interchangeably. § Abbreviations used are: heme, ferriprotoporphyrin IX; CD, circular dichroism: MCD, magnetic circular dichroism; epr, electron paramagnetic resonance; Kd, dissociation constant; [θ]231, molar ellipticity at 231 nm. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Fairley, N. H. 1938 Methaemalbumin (Pseudo-methaemoglobin). Nature 142: 1156–1157. 2 Heilmeyer, L. 1933. Medizinische Spektrophotometrie. G. Fischer. Jena , Germany . 3 Peters, T., Jr. 1970. Serum albumin. Advan. Clin. Chem. 13: 37–111. 4 Spector, A. A., K. John & J. E. Fletcher. 1969. Binding of long-chain fatty acids to bovine serum albumin. J. Lipid Res. 10: 56–67. 5 Jacobsen, J. 1969. Binding of bilirubin to human serum albumin - determination of the dissociation constants. FEBS Lett. 5: 112–114. 6 Allison, A. C. & W. AP Rees. 1957. The binding of haemoglobin by plasma proteins (haptoglobins). Brit. Med. J. 2: 1137–1143. 7 Neale, F. C., G. M. Aber & B. E. Northam. 1958. The demonstration of intravascular haemolysis by means of serum paper electrophoresis and a modification of Schumm's reaction. J. Clin. Path. 11: 206–219. 8 Muller-Eberhard, U. 1970. Hemopexin. New Eng. J. Med. 283: 1090–1094. 9 Braun, H. J. 1971. Eigenschaften, funktion und serumkonzentration des mcnschlichen hämopexins. Klin. Wochenschr. 49: 445–451. 10 Muller-Eberhard, U. & H. H. Liem. 1974. Hemopexin, the heme-binding serum β-glycoprotein. In Plasma Proteins, Vol. 1. A. C. Allison, Ed.: 35–53. Plenum Press. London , England . 11 Kosaki, T., T. Ikeda, Y. Kotani, et al. 1957. The affinities of cells and their formative elements for porphyrin bodies. XII. The affinity of cells and their formative elements for coproporphyrin I and III. Mie Med. J. 7: 305–312. 12 Sugita, Y. 1962. The role of particulate bound protoporphyrin in biosynthesis of heme. J. Biochem. 51: 436–440. 13 Koskelo, P., B. Bergrahm & I. Toivonen. 1971. Observations on the binding of 14C-labelled porphyrins by human plasma proteins. South Afr. Med. J. (special issue) 45: 167–169. 14 Schultze, H. E. & J. F. Heremans. 1966. Molecular Biology of Human Proteins. Vol. 1: Nature and Metabolism of Extracellular Proteins. Elsevier Publishing Co. New York , N.Y . 15 Yang, J. T. & P. Doty. 1957. The optical rotatory dispersion of polypeptides and proteins in relation to configuration. J. Amer. Chem. Soc. 79: 761–775. 16 Jacobsen, C. 1972. Chemical modification of the high-affinity bilirubin-binding site of human-serum albumin. Eur. J. Biochem. 27: 513–519. 17 Brown, S. B., T. C. Dean & P. Jones. 1970. Aggregation of ferrihaems. Dimerization and protolytic equilibria of protoferrihaem and deuteroferrihaem in aqueous solution. Biochem. J. 117: 733–739. 18 Rosenfeld, M. & D. M. Surgenor. 1950. Methemalbumin. Interaction between human serum albumin and ferriprotoporphyrin IX. J. Biol. Chem. 183: 663–677. 19 Keilin, J. 1944. Reaction of human serum albumin with haematin and haem. Nature 154: 120–121. 20 Fairley, N. H. 1941. Methaemalbumin. I. Clinical aspects. Quart. J. Med. 38: 95–114. 21 Holden, H. F. 1937. The combination with proteins of certain porphyrins. Aust. J. Exp. Biol. Med. Sci. 15: 409–421. 22 Fišer-Herman, M. & P. Davorin. 1953. Papierelektrophorese des haematin-albumins. Biochem. Z. 324: 96–103. 23 Péterfy, F., K. Rásky, I. Kiss & I. Tóth. 1971. Studies on albumin-haem complex formation. Ann. Immunol. Hung. 15: 101–111. 24 Liang, C. 1957. The formation of complexes between haemoglobins and plasma proteins in a variety of animals. Biochem. J. 66: 552–558. 25 Bunn, H. F. & J. H. Jandl. 1968. Exchange of heme among hemoglobins and between hemoglobin and albumin. J. Biol. Chem. 243: 465–475. 26 Baur, E. W. 1969. The evolution of methaemalbumin. Comp. Biochem. Physiol. 30: 657–664. 27 Muller-Eberhard, U. & H. H. Liem. 1968. Exchange of heme between human hemopexin, human albumin, rabbit hemopexin and rabbit albumin. Fed. Proc. 27: 723 (Abst. No. 2850). 28 Liem, H. H. & U. Muller-Eberhard. Unpublished observation. 29 Seery, V. L. & U. Muller-Eberhard. 1973. Binding of porphyrins to rabbit hemopexin and albumin. J. Biol. Chem. 248: 3796–3800. 30 Kaminsky, L. S., M. J. Byrne & A. J. Davison. 1972. Iron ligands in different forms of ferricytochrome c: The 620-nm band as a probe. Arch. Biochem. Biophys. 150: 355–361. 31 O'hagan, J. E. 1959. Decrease in acid strength of propionate side-chains of haematin on reduction to haem. Nature 184: 1808. 32 Daniels, C. A., C. Wagner, R. C. Hartmann & D. E. Jenkins. 1967. Spectral absorption characteristics of human methemalbumin. Amer. J. Clin. Path. 47: 631–637. 33 Little, H. N. & J. B. Neilands. 1960. Binding of haematin by human serum albumin. Nature 188: 913–915. 34 Liem, H. H. & U. Muller-Eberhard. 1971. Do heme and bilirubin have identical binding sites on the albumin molecule? Biochem. Biophys. Res. Commun. 42: 634–639. 35 Blauer, G., D. Harmatz & J. Snir. 1972. Optical properties of bilirubin-serum albumin complexes in aqueous solution. I. Dependence on pH. Biochim. Biophys. Acta 278: 68–88. 36 Morgan, W. T. & U. Muller-Eberhard. Unpublished observation. 37 Haurowitz, F. & H. Waelsch. 1929. Über die Bindung zwischen Eiweiss und prosthetischer Gruppe im Hamoglobin. Hoppe-Seyler'S Z. Physiol. Chem. 182: 82–96. 38 Gildemeister, H. 1937. Porphyrine und Serumeiweiss. Ein Beitrag zur Vehikelf-unktion der Serumeiweifßkörper. Z. Exp. Med. 102: 58–87. 39 Schwartz, S., M. H. Berg, I. Bossenmaier & H. Dinsmore. 1960. Determination of porphyrins in biological materials. In Methods of Biochemical Analysis. D. Click, Ed. Vol. 8: 227. Interscience Publishers. New York , N.Y . 40 Stenhagen, E. & E. K. Rideal. 1939. The interaction between porphyrins and lipoid and protein monolayers. Biochem. J. 33: 1591–1598. 41 Maehly, A. C. 1961. Haemin-protein binding in peroxidase and methaemalbumin. Nature 192: 630–632. 42 Mareček, Z., M. Jirsa & J. Kořínek. 1973. This binding of protoporphyrin to serum proteins. Clin. Chim. Acta 45: 409–413. 43 Koskelo, P., I. Toivonen & P. Rintola. 1970. The binding of 14C-labelled porphyrins by plasma proteins. Clin. Chim. Acta 29: 559–565. 44 Schwerd, W. 1958. Die bindung des hämatins an bluteiweissstoffe. Hoppe-Seyler's Z. Physiol. Chem. 310: 114–119. 45 Aber, G. M. & D. S. Rowe. 1960. The binding of haematin by serum proteins. Brit. J. Haemal. 6: 160–165. 46 Biserte, G., R. Havez & J. Laturaze. 1960. Caractérisation électrophorétique et immunologique de séromucoïde β1 dans le serum sanguin humain. Compt. Rend. Soc. Biol. 11: 2061–2066. 47 Grabar, P., C. De Vaux St-Cyr & H. Cleve. 1960. Présence de β1 B-globuline dans les extraits perchloriques de sérums humains normaux. Bull. Soc. Chim. Biol. 42: 853–856. 48 Hirschfeld, J. 1960. Characterization of precipitating components in normal human sera obtained by an immuno-electrophoretic technique. Acta Path. Microbiol. Scand. 49: 255–269. 49 Nyman, M. 1960. On plasma proteins with heme or hemoglobin binding capacity. Scand. J. Clin. Lab. Invest. 12: 121–130. 50 Tombs, M. P. 1960. A haemoglobin-binding β-globulin in human serum. Nature 186: 1055–1056. 51 Wheby, M. S., O. Barrett & W. H. Crosby. 1960. Serum protein binding of myoglobin, hemoglobin and hematin. Blood 16: 1579–1585. 52 Hughes Jones, N. C., B. Gardner & R. Helps. 1961. Observations on the binding of haemoglobin and haematin by serum proteins in the rabbit, rat and guinea pig. Biochem J. 79: 220–223. 53 Kořińek, J., E. Paluska & O. Mach. 1961. Some notes concerning serum β1-haptoglobin. Clin. Chim. Acta 6: 388–392. 54 Shinowara, G. Y. & M. I. Walters. 1963. Hematin-studies on protein complexes and determination in human plasma. Amer. J. Clin. Path. 40: 113–122. 55 Bremner, K. C. 1964. Studies on haptoglobin and haemopexin in the plasma of cattle. Aust. J. Exp. Biol. Med. Sci. 42: 643–656. 56 Drabkin, D. L. 1971. Heme binding and transport - A spectrophotometric study of plasma glycoglobulin hemochromogens. Proc. Nat. Acad. Sci. USA 68: 609–613. 57 Becker, W. 1967. Quantitative immunologische bestimmung von plasmaproteinen durch elektrophorese in antiserum-haltigem agarose gel. Klin. Wschr. 45: 389–390. 58 Rosen, H. & D. A. Sears. 1969. Spectral properties of hemopexin-heme: The Schumm test. J. Lab. Clin. Med. 74: 941–945. 59 Klapper, D. G., M. A. Cuchens & L. W. Clem. 1972. Induction of hemopexin by streptococcal cells in aged mice. Lab. Invest. 26: 731–734. 60 Grunder, A. A. 1966. Inheritance of a heme-binding protein in rabbits. Genetics 54: 1085–1093. 61 Baker, L. N. 1967. A new allele, Hp4, in the hemopexin system in pigs. Vox Sang. (Basel) 12: 397–400. 62 Stewart, R. E. & E. W. Lovrien. 1971. Haemopexin in human serum: A search for genetic polymorphism. Ann. Hum. Genet. Lond. 36: 19–24. 63 Spiro, R. G. 1970. Glycoproteins. Annu. Rev. Biochem. 39: 599–638. 64 Seery, V. L., G. Hathaway & U. Muller-Eberhard. 1972. Hemopexin of human and rabbit: Molecular weight and extinction coefficient. Arch. Biochem. Biophys. 150: 269–272. 65 Hrkal, Z. & U. Muller-Eberhard. 1971. Partial characterization of the heme-binding serum glycoproteins rabbit and human hemopexin. Biochemistry 10: 1746–1750. 66 Schultze, H. E., K. Heide & H. Haupt. 1961. Charakterisierung von hochgere-inigtem hämopexin. Naturwissenschaften 22: 1–3. 67 Conway, T. P., W. T. Morgan, H. H. Liem & U. Muller-Eberhard. 1974. J. Biol. Chem. In press. 68 Morell, A. G., R. A. Irvine, I. Sternlieb, I. H. Scheinberg & G. Ashwell. 1968. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. J. Biol. Chem. 243: 155–159. 69 Heide, K., H. Haupt, K. Störiko & H. E. Schultze. 1964. On the heme-binding capacity of hemopexin. Clin. Chim. Acta 10: 460–469. 70 Harbury, H. A., J. R. Cronin, M. W. Fanger, et al. 1965. Complex formation between methionine and a heme peptide from cytochrome c. Proc. Nat. Acad. Sci. USA 54: 1658–1664. 71 Muller-Eberhard, U. & K. Grizzuti. 1971. Conformational studies on human and rabbit plasma hemopexin and on the effect of ligands on the rabbit heme-hemopexin complex. Biochemistry 10: 2062–2066. 72 Morgan, W. T. & U. Muller-Eberhard. 1972. Interactions of porphyrins with rabbit hemopexin. J. Biol. Chem. 247: 7181–7187. 73 Hrkal, Z., I. Kalousek & Z. Vodrážka. 1974. Heme binding and equilibria between hemoglobin and hemopexin. Eur. J. Biochem. 43: 73–78. 74 Conway, T. P. & U. Muller-Eberhard. Unpublished observation. 75 Javid, J. M. H. Fuhrman, H. H. Liem, et al. 1972. Immunologic differentiation of free and heme-bound rabbit hemopexin. J. Lab. Clin. Med. 80: 817–821. 76 Peggion, E., A. Cosani, A. S. Verdini et al. 1968. Conformational studies on poly-L-tryptophan: circular dichroism and X-ray diffraction studies. Biopolymers 6: 1477–1486. 77 Bearden, A. J., W. T. Morgan & U. Muller-Eberhard. 1974. Biochem. Biophys. Res. Commun. In press. 78 Loew, G. M. H. 1970. An analysis of the electron spin resonance of low spin ferric heme compounds. Biophys. J. 10: 196–212. 79 Vickery, L. E. Personal communication. 80 Vickery, L. E. Unpublished observation. 81 Morgan, W. T. & U. Muller-Eberhard. 1974. Modification of histidine residues of rabbit hemopexin. In preparation. 82 Morgan, W. T. & U. Muller-Eberhard. 1974. Modification of tryptophan residues of rabbit hemopexin by N-bromosuccinimide. Enzyme (Basel) 17: 108–115. 83 Soininen, R. & N. Ellfolk. 1973. Pseudomonas cytochrome c peroxidase. V. Absorption spectra of the enzyme and of its compounds with ligands. Inhibition of the enzyme by cyanide and azide. Acta Chem. Scand. 27: 35–46. 84 Muller-Eberhard, U., H. H. Liem, C. A. Yu & I. C. Gunsalus. 1969. Removal of heme from cytochrome P-450cam by hemopexin and apomyoglobin associated with loss of P-450 hydroxylase activity. Biochem. Biophys. Res. Commun. 35: 229–235. 85 Maines, M. D., M. W. Anders & U. Muller-Eberhard. 1974. Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins. Molec. Pharmacol. 10: 204–213. 86 Muller-Eberhard, U., H. H. Liem, A. Hanstein & P. A. Saarinen. 1969. Studies on the disposal of intravascular heme in the rabbit. J. Lab. Clin. Med. 73: 210–218. 87 Sears, D. A. 1970. Disposal of plasma heme in normal man and patients with intravascular hemolysis. J. Clin. Invest. 49: 5–14. 88 Muller-Eberhard, U. & H. Cleve. 1963. Immunoelectrophoretic studies of the β1-haem-binding globulin (haemopexin) in hereditary haemolytic disorders. Nature 197: 602–603. 89 Meiers, H. G. & H. Ippen. 1968. Ahämopexinämie bei porphyria cutanea tarda. Klin. Wschr. 46: 560–561. 90 Braun, H. J. & F. W. Aly. 1970. Verminderungen des zirkulierenden serum-hämopexins bei nicht-hämolytischen erkrankungen. Klin. Wschr. 48: 760–761. 91 Braun, H. J. & F. W. Aly. 1971. Die klinische bedeutung der quantitativen serum-hämopexinbestimmung im vergleich zum haptoglobin. Klin. Wschr. 49: 451–458. 92 Bradley, T. B., Jr., R. C. Wohl, S. B. Murphy, et al. 1972. Properties of Hemoglobin Bryn Mawr, β85 Phe → Ser, a new spontaneous mutation producing an unstable hemoglobin with high oxygen affinity. Blood 40: 947. 93 Wrightstone, R. N., J. B. Wilson, C. A. Reynolds, et al. 1973. Hb-Genova (α2β228 (B10) Leu → Pro): Methods for detection and analysis of unstable hemoglobins. Clin. Chim. Acta 44: 217–227. 94 Rieder, R. F. & T. B. Bradley, Jr. 1968. Hemoglobin Gun Hill: An unstable protein associated with chronic hemolysis. Blood 32: 355–369. 95 Egan, E. L. & V. F. Fairbanks. 1973. Postsplenectomy erythrocytosis in Hemoglobin Köln disease. New Eng. J. Med. 288: 929–931. 96 Keeling, M. M., L. L. Ogden, R. N. Wrightstone, et al. 1971. Hemoglobin Louisville (β42 (CD1) Phe → Leu): An unstable variant causing mild hemolytic anemia. J. Clin. Invest. 50: 2395–2402. 97 Fairbanks, V. F., R. W. Opfell & E. O. Burgert, Jr. 1969. Three families with unstable hemoglobinopathies (Koln, Olmsted and Santa Ana) causing hemolytic anemia with inclusion bodies and pigmenturia. Amer. J. Med. 46: 344–359. 98 Shaeffer, J. R. 1973. Structure and synthesis of the unstable Hemoglobin Sabine (α2β291 Leu → Pro) J. Biol. Chem. 248: 7473–7480. 99 Opfell, R. W., P. A. Lorkin & H. Lehmann. 1968. Hereditary non-spherocytic haemolytic anaemia with post-splenectomy inclusion bodies and pigmenturia caused by an unstable Haemoglobin Santa Anna - β88 (F4) leucine → pro line. J. Med. Genet. 5: 292–297. 100 Stamatoyannopoulos, G., J. T. Parer & C. A. Finch. 1969. Physiologic implications of a hemoglobin with decreased oxygen affinity (Hemoglobin Seattle). New Eng. J. Med. 281: 915–919. 101 Hanstein, A. & U. Muller-Eberhard. 1968. Concentration of serum hemopexin in healthy children and adults and in those with a variety of hematological disorders. J. Lab. Clin. Med. 71: 232–239. 102 Eyster, M. E., T. S. Edgington, H. H. Liem & U. Muller-Eberhard. 1972. Plasma hemopexin levels following aortic valve replacement: A valuable screening test for assessing the severity of cardiac hemolysis. J. Lab. Clin. Med. 80: 112–116. 103 Sutton, H. E. 1970. The haptoglobins. Progr. Med. Genet. 7: 163–216. 104 Murray-Lyon, I. M. & R. Williams. 1974. Quantitative immunoelectrophoresis of serum proteins in acute viral hepatitis, extra-hepatic obstructive jaudice, primary biliary cirrhosis and idiopathic haemochromatosis. Clin. Chim. Acta. 51: 303–308. 105 Muller-Eberhard, U. 1973. Link of porphyrias to metabolism of hemopexin (Hx), the most avid serum binder of porphyrins. J. Clin. Invest 52: 59a. 106 Ross, J. D. & U. Muller-Eberhard. 1970. Pharmacologic induction of serum hemopexin by 3-methylcholanthrene and allylisopropylacetamide. J. Lab. Clin. Med. 75: 694–702. 107 Ross, J. D. & U. Muller-Eberhard. 1970. In vivo effect of inhibitors of heme biosynthesis on serum hemopexin (Hx) levels and its pharmacological induction. Biochem. Biophys. Res. Commun. 41: 1486–1493. 108 Smibert, E., H. H. Liem & U. Muller-Eberhard. 1972. Studies on the induction of serum hemopexin by pentobarbital and polycyclic hydrocarbons. Biochem. Pharmacol. 21: 1753–1761. 109 Manuel, Y., M. C. Defontaine, J. J. Bourgoin, et al. 1971. Serum haemopexin levels in patients with malignant melanoma. Clin. Chim. Acta 31: 485–486. 110 Tio, T. H., B. Leijnse, A. Jarrett & C. Rimington. 1957. Acquired porphyria from a liver tumour. Clin. Sci. 16: 517–527. 111 Thompson, R. P. H., D. C. Nicholson, T. Farnan, et al. 1970. Cutaneous porphyria due to a malignant primary hepatoma. Gastroenterology 59: 779–783. 112 Cleve, H., K. Alexander, H. J. Mitzkat, et al. 1968. Serumglykoproteine beim Diabetes mellitus: quantitative immunologische Bestimmung von saurem αI-Glykoprotein, Gc, α2-Makroglobulin und Hämopexin bei Diabetikem mit und ohne Angiopathien. Diabetologia 4: 48–55. 113 Amin, A. H., H. G. Clarke, T. Freeman, I. M. Murray-Lyon et al. 1970. Studies by quantitative immunoelectrophoresis on iron binding proteins in haemochromatosis. Clin. Sci. 38: 613–616. 114 Wochner, R. D., I. Spilberg, A. II O., H. H. Liem & U. Muller-Eberhard. 1974. Hemopexin metabolism in sickle cell disease, porphyrias, and control subjects: Effects of heme injection. New Eng. J. Med. 290: 822–826. 115 Lane, R. S., D. M. Rangeley, H. H. Liem, S. Wormsley & U. Muller-Eberhard. 1972. Hemopexin metabolism in the rabbit. J. Lab. Clin. Med. 79: 935–941. 116 Lane, R. S., D. M. Rangeley, H. H. Liem, S. Wormsley & U. Muller-Eberhard. 1973. The effect of intravascular heme on the rate of hemopexin catabolism in the rabbit. Brit. J. Haem. 25: 533–540. 117 Muller-Eberhard, U., C. Bosman & H. H. Liem. 1970. Tissue localization of the heme-hemopexin complex in the rabbit and the rat as studied by light microscopy with the use of radioisotopes. J. Lab. Clin. Med. 76: 426–431. 118 Liem, H. H. 1974. Hepatic uptake of heme and hemopexin but not albumin. Biochem. Biophys. Acta 343: 546–550. 119 Koskelo, P., M. Kekki, P. Mustajoki & E. Valmet. 1973. Turnover of 125I-labelled hemopexin in man. Enzyme (Basel) 17: 116–121. 120 Gitlin, D. & A. Biasucci. 1969. Development of γG, γA, γM, β1C/β1A, C'1 esterase inhibitor, ceruloplasmin, transferrin, hemopexin, haptoglobin, fibrinogen, plasminogen, α1-antitrypsin, orosomucoid, β-lipoprotein, α2-macroglobulin, and prealbumin in the human conceptus. J. Clin. Invest. 48: 1433–1446. 121 Muller-Eberhard, U. 1973. Hemopexin (Hx) is synthesized only by the liver in the human fetus. Ped. Res. 7: 86. 122 Snyder, A. L. & R. Schmid. 1965. The conversion of hematin to bile pigment in the rat. J. Lab. Clin. Med. 65: 817–824. 123 Granick, S. & S. Sassa. 1971. δ-Aminolevulinic acid synthetase and the control of heme and chlorophyll synthesis. In Metabolic Pathways, Vol. 5 (Metabolic Regulation). H. J. Vogel, Ed.: 77–141. Academic Press. New York , N.Y . Citing Literature Volume244, Issue1The Biological Role of Porphyrins and Related StructuresApril 1975Pages 624-649 ReferencesRelatedInformation
Referência(s)