Portal de Periódicos da CAPES

Biosynthesis of vitamin B12: the macrocycle and studies on the geminal methyl groups of ring c

1973; Royal Society of Chemistry; Issue: 12 Linguagem: Inglês

10.1039/c39730000404

2050-5639

Alan R. Battersby, Masataka Ihara, Edward McDonald, Janet Stephenson, Bernard T. Golding,

Metabolism and Genetic Disorders

The biosynthesis of vitamin B12 is studied by 13C-spectroscopy on the derived heptamethyl ester (4); work with amino[5-13C]lavulinic acid and [Me-13C]- methionine confirms that seven peripheral methyl groups are derived from methionine and proves that one of these is the pro-R methyl group on ring c.