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Potential for Ultrafast Protein Separations with Capillary-Channeled Polymer (C-CP) Fiber Columns

2005; Bentham Science Publishers; Volume: 13; Issue: 1 Linguagem: Inglês

10.2174/092986606774502144

1875-5305

Don Nelson, Robin L. Marcus,

Microfluidic and Capillary Electrophoresis Applications

Capillary-channeled polymer (C-CP) fibers are demonstrated as a potential stationary phase for liquid chromatography separation of protein mixtures. Separation of a synthetic mixture of four proteins is accomplished within a 45-second window using a conventional revered-phase (RP) gradient, at a mobile phase flow rate of 7 mL/min (10,200 mm/min).