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Use of DNA probes from the 5′ flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus

1986; Elsevier BV; Volume: 16; Issue: 2 Linguagem: Inglês

10.1016/0198-8859(86)90042-x

1879-1166

Karyn J. Steere, B Sidwell, Robin J. Leach, F E Ward, Joel D. Taurog, Harry T. Orr,

Reproductive System and Pregnancy

Two DNA probes isolated from the region 5' to the HLA-B gene are described. One of these, pCH6, detects a TaqI polymorphism which is correlated with serological alleles of HLA-B. Both probes are used to show a high level of DNA sequence homology between the 5' flanking region of HLA-B and HLA-C.