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Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill

2008; Elsevier BV; Volume: 591; Issue: 1-3 Linguagem: Inglês

10.1016/j.ejphar.2008.06.074

1879-0712

Lian Guo, Trần Mạnh Hưng, Ki Hwan Bae, Eun Myoung Shin, Hong Zhou, Yoo Na Hong, Sam Sik Kang, Hyun Pyo Kim, Yeong Shik Kim,

NF-κB Signaling Pathways

Schisandrin is the main active ingredient isolated from the fruit of Schisandra chinensis Baill. Recent studies have demonstrated that schisandrin exhibits anti-oxidative effects in vivo. In the present study, the effect of schisandrin on plasma nitrite concentration in lipopolysaccharide (LPS)-treated mice was evaluated. It also significantly inhibited carrageenan-induced paw edema and acetic acid-induced vascular permeability in mice. Furthermore, schisandrin had a protective effect on lipopolysaccharide (LPS)-induced sepsis. In vitro, our results are the first that show that the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide (NO) production, prostaglandin E2 (PGE2) release, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, which in turn results from the inhibition of nuclear factor-kappaB (NF-κB), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activities in a RAW 264.7 macrophage cell line.