Portal de Periódicos da CAPES

Potentiation of warfarin by trimethoprim-sulfamethoxazole

1980; Elsevier BV; Volume: 16; Issue: 6 Linguagem: Inglês

10.1016/0090-4295(80)90568-3

1527-9995

Joel M. Kaufman, H. Earl Fauver,

Blood disorders and treatments

Potentiation of warfarin by trimethoprim-sulfamethoxazole (TMP-SMX) has been reported occasionally but not in the urologic literature. Three cases are presented in which significant bleeding developed when TMP-SMX was added for the patient already on warfarin anticoagulants. The mechanism of this interaction is uncertain but probably involves competitive protein binding by the two drugs.