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Use of Sealants in Pancreatic Surgery: Critical Appraisal of the Literature

2009; Karger Publishers; Volume: 26; Issue: 1 Linguagem: Inglês

10.1159/000191284

1421-9883

Abe Fingerhut, Nicolas Veyrie, Toufik Ata, N. Alexakis, Emmanuel Leandros,

Body Contouring and Surgery

<i>Background/Aims:</i> Fibrin sealants containing both fibrin and thrombin have been used to control bleeding, reinforce suture lines and enhance tissue healing. However, the literature provides contradictory results. <i>Methods:</i> A systematic literature search was performed to determine the use of fibrin sealants in pancreatic surgery. These articles were then critically appraised according to their methodologies, outcomes and conclusions. <i>Results:</i> Twenty-four studies were found, including 6 controlled randomized trials. Of these, 16 studies were analyzed. Many methodological flaws and lack of consistency in definitions were found, making comparisons between studies difficult if not impossible. <i>Conclusion:</i> Because of the heterogeneity and lack of high-level evidence, the current literature does not allow us any conclusion: neither is there proof that fibrin sealants are of any real utility in pancreatic surgery, nor that they do not work. Further large-scale controlled trials are necessary before concluding that they do or do not provide any advantages in pancreatic surgery.