Adjuvant activity of chitin derivatives in mice and guinea-pigs
1985; Elsevier BV; Volume: 3; Issue: 5 Linguagem: Inglês
10.1016/0264-410x(85)90127-6
ISSN1873-2518
AutoresKeiko Nishimura, Shin‐Ichiro Nishimura, Norio Nishi, Fumio Numata, Yukiko Tone, Seiichi Tokura, Ichiro Azuma,
Tópico(s)Nanocomposite Films for Food Packaging
ResumoAdjuvant activity of chitin derivatives was examined in guinea-pigs and mice. Among derivatives of chitin tested, 30 and 70% deacetylated chitin (DAC-30 and DAC-70), were active as adjuvants for the circulating-antibody formation to bacterial alpha-amylase and for the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine. DAC-70 enhanced the helper T cell function, the generation of alloreactive cytotoxic T lymphocytes, and the activity of natural killer cells in mice, however, it was inactive as mitogen. Other derivatives of chitin showed weaker or no adjuvant activity compared with DAC-70. Carboxymethyl-, hydroxyethyl and dihydroxypropyl-chitin showed weak mitogenic activities on normal spleen cells.
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