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Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989; Nature Portfolio; Volume: 337; Issue: 6205 Linguagem: Inglês

10.1038/337368a0

1476-4687

Paul R. Clapham, Jonathan Weber, Denise Whitby, Kenneth McIntosh, Angus Dalgleish, Paul J. Maddon, Keith C. Deen, Raymond W. Sweet, Robin A. Weiss,

Immune Cell Function and Interaction

The CD4 antigen has been subverted as a receptor by the human and simian immunodeficiency viruses (HIV-1, HIV-2 and SIV). Several groups have reported that recombinant, soluble forms of the CD4 molecule (sCD4) block the infection of T lymphocytes by HIV-1, as CD4 binds the HIV envelope glycoprotein, gp120, with high affinity. We now report that sCD4 blocks diverse strains of HIV-1, HIV-2 and SIV, but is less effective for HIV-2. The blocking effect is apparent even after adsorption of virions to CD4 cells. Soluble CD4 prevents HIV infection of T-lymphocytic and myelomonocytic cell lines, but neither sCD4 nor anti-CD4 antibodies inhibit infection of glioma and rhabdomyosarcoma cell lines.