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Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing

2014; National Academy of Sciences; Volume: 111; Issue: 16 Linguagem: Inglês

10.1073/pnas.1319389111

1091-6490

Ivan V. Zvyagin, Mikhail V. Pogorelyy, Marina E. Ivanova, Ekaterina A. Komech, Mikhail Shugay, Dmitriy A. Bolotin, Andrey Shelenkov, Alexey A. Kurnosov, Dmitriy B. Staroverov, Dmitriy M. Chudakov, Yuri B. Lebedev, Ilgar Z. Mamedov,

vaccines and immunoinformatics approaches

Significance The power of adaptive immunity in humans is realized through the hypervariable molecules: the T-cell receptors (TCRs). Each of those is built from genetically encoded parts with the addition of random nucleotides finally forming individual TCR repertoire. Despite that the individual TCR repertoire potentially can include 10 11 –10 14 different variants, substantially less molecules are found in a single individual. The particular genetic impact on the final set of TCR molecules is still poorly understood. In this study, for the first time to the best of our knowledge, we compare deep TCR repertoires of genetically identical twins. We found that, although TCR repertoires of any pair of individuals have the same amount of identical receptors, twin repertoires share certain specific features.