Immunogenicity and Reactogenicity to Haemophilus influenzae Type b (Hib) Conjugate Vaccine Among Rural Alaska Adults
2006; Landes Bioscience; Volume: 2; Issue: 1 Linguagem: Inglês
10.4161/hv.2.1.2445
ISSN1554-8619
AutoresCatherine Dentinger, Thomas W. Hennessy, Lisa Bulkow, Alisa Reasonover, Sandra Romero‐Steiner, Patricia Holder, Patricia Gómez de León, George M. Carlone, Debra J. Parks, Alan J. Parkinson, Rosalyn Singleton, Orin S. Levine, Jay C. Butler,
Tópico(s)Influenza Virus Research Studies
ResumoAbstractBackground: Despite routine vaccination and declining disease rates, Haemophilusinfluenzae type b (Hib) invasive disease still occurs in rural Alaska. Colonization studiesindicate persistent transmission of Hib among village residents, including adults. As partof a project to eliminate Hib carriage in 3 rural villages, we evaluated a cohort of Alaskaadults for antibody response and reactogenicity to a single dose of Hib conjugate vaccine(HbOC).Methods: 75 previously unvaccinated, randomly-selected adults in one village received asingle dose of HbOC vaccine and completed a side-effects diary. Sera and oropharyngealspecimens were collected at baseline, 2 months and 1 year.Results: No participants were colonized with Hib or reported serious side-effects. Atbaseline, 97% of adults had IgG anti-PRP concentrations > 0.15 µg/mL, 69% >1 µg/mL,and 28% > 5 µg/mL. Two months post-vaccination, 100% of participants hadconcentrations > 0.15 µg/mL, 93% >1 µg/mL, and 86% >5 µg/mL. After 1 year, 98% hadIgG anti-PRP concentrations > 0.15 µg/mL, 86% > 1 µg/mL, and 67% >5 µg/mL. GMCswere 1.9, 33.3 and 8.4 µg/mL at baseline, 2 months and 1 year post-vaccine, respectively(p
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