Clinical Assessment of Atherosclerotic Lesions
2002; Lippincott Williams & Wilkins; Volume: 106; Issue: 11 Linguagem: Inglês
10.1161/01.cir.0000030315.80547.3f
ISSN1524-4539
Autores Tópico(s)Coronary Interventions and Diagnostics
ResumoHomeCirculationVol. 106, No. 11Clinical Assessment of Atherosclerotic Lesions Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBClinical Assessment of Atherosclerotic LesionsEmerging From Angiographic Shadows John R. Guyton John R. GuytonJohn R. Guyton From Duke University Medical Center, Department of Medicine, Sarah W. Stedman Center for Nutritional Studies, Durham, NC. Originally published10 Sep 2002https://doi.org/10.1161/01.CIR.0000030315.80547.3FCirculation. 2002;106:1308–1309In the mid to late 1800s, the light microscopic features of atherosclerosis were discovered as Virchow and others used techniques that were novel at the time for paraffin embedding, sectioning, and staining of tissues.1 From then until the past few years, detailed characterization of atherosclerotic lesions has been limited to autopsied or excised tissues, which display only a single time point per specimen. Today, the goal of visualizing and characterizing the diseased arterial wall in living patients has become a reality with the use of several techniques. In this issue of Circulation, Cai and colleagues2 demonstrate that magnetic resonance can provide a living "biopsy" of carotid atherosclerotic plaques. Preoperative MRIs correlated well with paraffin section histology of endarterectomy specimens, classified by criteria of the Committee on Vascular Lesions of the Arteriosclerosis Council.3See p 1368Because the clinician has such difficulty defining atherosclerosis in living patients, this ubiquitous disease must be managed indirectly. Downstream effects on end-organ ischemia and infarction are measured. An offending plaque may be bypassed or it may be cracked at the edge and displaced by stretching of the underlying tissue. The antecedents to atherosclerosis, termed risk factors, are treated mostly in terms of their relation to end-organ events. Clinical trials have taught us how changing certain risk factors can affect those events. All of this happens with scant knowledge of atherosclerotic lesion progression in the angiographic shadows.The obscurity of atherosclerosis to the clinician has led to a largely dichotomized approach. If ischemia or infarction has not yet occurred, then the job of the clinician is to identify the risk factors and treat them where evidence for efficacy is strong. If ischemia or infarction has occurred, the first task is often to assess and remedy the impaired coronary flow, with a heightened program of risk factor modification coming next.The approach may change as new technology brings atherosclerosis out of the shadows and into the light. MRI is the most elegant and perhaps ultimately the most useful of several techniques for characterizing lesions. Carotid B-mode ultrasound can provide intima-media thickness measurements predictive of both cerebral and coronary vascular events.4 Coronary intravascular ultrasound has shown that patients with normal or minimally abnormal angiograms may have extensive nonstenosing coronary atherosclerosis.5 The ankle-brachial index, a venerable measure of ileofemoral atherosclerosis, predicts cardiovascular and all-cause mortality.6The determination of coronary calcium deposits by enhanced computed tomography of the heart is entering clinical practice faster than many would like. Coronary calcium scoring provides a reasonably good estimate of the total burden of coronary atherosclerosis.7 The ability of coronary calcium scoring to predict clinical coronary events has been found to be equal to estimation on the basis of the number of coronary arteries with >50% angiographic stenosis8 and either equal to or better than the Framingham logistical estimate on the basis of multiple risk factors.9,10 Key questions not yet answered by prospective data are whether year-to-year changes in the calcium score may be responsive to treatment and/or predictive of events.11The ruptured or ulcerated atherosclerotic plaque is the most dangerous lesion, but evidence indicates that plaque rupture is frequently silent, unaccompanied by clinical symptoms. Recently, MRI of the myocardium with gadolinium contrast has demonstrated that microinfarcts can be visualized in patients with advanced coronary atherosclerosis with12 or without13 coronary intervention. If microinfarcts are caused by fibrin-platelet emboli from ulcerated plaques, clinical treatments that stabilize plaques might be validated by demonstrating the cessation of new microinfarct formation.The National Institutes of Health–funded Multi-Ethnic Study of Atherosclerosis (MESA) multi-center trial14 is studying the progression of human atherosclerosis as examined by many of these techniques, including ankle-brachial index, carotid B-mode ultrasound, computed tomography of coronary arteries, and MRI of the heart, as well as by stimulated vasodilation of the brachial artery. The population-based, longitudinal data supplied by this and other studies will provide an essential foundation for treatment studies and, ultimately, changes in clinical practice.Current clinical paradigms, as indicated earlier, focus on the antecedent risk factors and the sequelae of end-organ ischemia/infarction, largely omitting the intermediary role of the atherosclerotic lesion in the pathophysiological sequence. The future clinical paradigms will increasingly include atherosclerosis in the middle—that is, risk factors leading to definable, quantifiable atherosclerosis, which in turn lead to myocardial and brain ischemia/infarction.Nonetheless, evidence-based medicine reminds us that what really counts is morbidity and mortality. Will we want to treat a patient merely because her carotid plaque has excessive lipid content and a thin fibrous cap? Will that qualify as a surrogate or a biomarker for clinical events? Today we treat abnormal glucose, low-density lipoprotein cholesterol, and blood pressure partly or largely for the purpose of reducing excess risk of the atherosclerotic events predicted by these parameters. It makes sense that we will someday apply metabolic and pharmacological treatment to high-risk plaques for the same reason. Much remains to be done in assigning clinical risk estimates to lesion characteristics and also to time- and treatment-dependent changes in lesion characteristics as quantified by the new techniques.Advances in diagnosis prosper when they march hand-in-hand with advances in treatment. We stand at the threshold of accurate noninvasive assessment of atherosclerosis. Is there a corresponding ability to treat atherosclerosis effectively by metabolic or pharmacological means? The answer is yes. In the context of noninvasive lesion assessment, statins have been shown to reduce the progression of carotid intima-media thickness defined by ultrasound,15,16 and high-dose atorvastatin achieved regression in patients with familial hypercholesterolemia.17Corti et al18 reported in an earlier issue of Circulation a longitudinal, uncontrolled study of the effect of simvastatin on atherosclerotic plaque dimensions by use of MRI. After 12 months of simvastatin treatment, vessel wall thickness and area were significantly reduced in the aorta and carotid arteries without a change in vessel lumen area. In another remarkable study, Zhao et al19 examined carotid plaque composition quantitatively by MRI in 8 patients with combined hyperlipidemia who had been treated intensively with lovastatin, niacin, and colestipol for 10 years. An untreated, nonrandomized control group was composed of 8 patients matched for age and baseline lipoproteins. In the untreated group, the atherosclerotic lipid core comprised 17% of carotid intima-media cross-sectional area. In the treated group, only 1% of the cross-sectional area belonged to the lipid core (P=0.01 for the comparison). Thus, the lipid core seemed to be almost eliminated from the lesions by metabolic/pharmacological treatment. The 8 treated patients were randomly chosen from a larger group of 60 patients treated intensively, and the larger group experienced only 3 major coronary events (cardiac death or myocardial infarction) over 10 years, or 0.5% per year.19If randomized clinical trials confirm these results, a paradigm shift in atherosclerosis treatment will begin. Most risk factors presumably influence atherothrombotic events via their effects on lesions, although this hypothesis will require rigorous testing. If this is proven, the risk factors may be viewed as 2 steps removed from clinical events, with lesions just 1 step away. Ultimately, one can foresee a new clinical paradigm that includes the assessment of atherosclerotic lesions in addition to risk factors fitted to an evidence-based model of end-organ and clinical risk reduction.The opinions expressed in this editorial are not necessarily those of the editors or of the American Heart Association.FootnotesCorrespondence to John R. Guyton, MD, Duke University Medical Center, Department of Medicine, PO Box 3510, Baker House, Room 281, Trent Dr, Durham, NC 27710. E-mail [email protected] References 1 Nezelof C, Seemayer TA. The history of pathology: an overview.In: Damjanov I, Linder J, eds. Anderson's Pathology. St Louis, Mo: Mosby; 1996:1–11.Google Scholar2 Cai J-M, Hatsukami TS, Ferguson MS, et al. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation. 2002; 106: 1368–1373.LinkGoogle Scholar3 Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995; 92: 1355–1374.CrossrefMedlineGoogle Scholar4 Furberg CD, Byington RP, Riley W. B-mode ultrasound: a noninvasive method for assessing atherosclerosis.In: Willerson JT, Cohn JN, eds. Cardiovascular Medicine. New York, NY: Churchill Livingston; 1995:1182–1187.Google Scholar5 Nissen SE, Yock P. Intravascular ultrasound: novel pathophysiological insights and current clinical applications. Circulation. 2001; 103: 604–616.CrossrefMedlineGoogle Scholar6 Criqui MH, Coughlin SS, Fronek A. Noninvasively diagnosed peripheral arterial disease as a predictor of mortality: results from a prospective study. Circulation. 1985; 72: 768–773.CrossrefMedlineGoogle Scholar7 Rumberger JA, Simons DB, Fitzpatrick LA, et al. Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area: a histopathologic correlative study. Circulation. 1995; 92: 2157–2162.CrossrefMedlineGoogle Scholar8 Detrano RC, Hsiai T, Wang S, et al. Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography. J Am Coll Cardiol. 1996; 27: 285–290.CrossrefMedlineGoogle Scholar9 Detrano RC, Wong ND, Doherty TM, et al. Coronary calcium does not accurately predict near-term future coronary events in high-risk adults. Circulation. 1999; 99: 2633–2638.CrossrefMedlineGoogle Scholar10 Arad Y, Spadaro LA, Goodman K, et al. Prediction of coronary events with electron beam computed tomography. J Am Coll Cardiol. 2000; 36: 1253–1260.CrossrefMedlineGoogle Scholar11 Callister TQ, Raggi P, Cooil B, et al. Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography. N Engl J Med. 1998; 339: 1972–1978.CrossrefMedlineGoogle Scholar12 Ricciardi MJ, Wu E, Davidson CJ, et al. Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation. Circulation. 2001; 103: 2780–2783.CrossrefMedlineGoogle Scholar13 Wu E, Judd RM, Vargas JD, et al. Visualisation of presence, location, and transmural extent of healed Q- wave and non-Q-wave myocardial infarction. Lancet. 2001; 357: 21–28.CrossrefMedlineGoogle Scholar14 National Institutes of Health. Multi-Ethnic Study of Atherosclerosis (MESA). Available at: http://clinicaltrials.gov/ct/gui/show/NCT00005487. Accessed August 11, 2002.Google Scholar15 Pitt B, Mancini GB, Ellis SG, et al. Pravastatin limitation of atherosclerosis in the coronary arteries (PLAC I): reduction in atherosclerosis progression and clinical events. PLAC I Investigation. J Am Coll Cardiol. 1995; 26: 1133–1139.CrossrefMedlineGoogle Scholar16 Crouse JR, Byington RP, Bond MG, et al. Pravastatin, lipids, and atherosclerosis in the carotid arteries (PLAC-II). Am J Cardiol. 1995; 75: 455–459.CrossrefMedlineGoogle Scholar17 Smilde TJ, van Wissen S, Wollersheim H, et al. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet. 2001; 357: 577–581.CrossrefMedlineGoogle Scholar18 Corti R, Fayad ZA, Fuster V, et al. Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation. 2001; 104: 249–252.CrossrefMedlineGoogle Scholar19 Zhao XQ, Yuan C, Hatsukami TS, et al. Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study. Arterioscler Thromb Vasc Biol. 2001; 21: 1623–1629.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Rassaf T, Steiner S and Kelm M (2013) Postoperative Care and Follow-Up After Coronary Stenting, Deutsches Ärzteblatt international, 10.3238/arztebl.2013.0072 (2011) Exercise McDonald's Blood Flow in Arteries, 10.1201/b13568-32, (567-582) Meding J, Urich M, Licha K, Reinhardt M, Misselwitz B, Fayad Z and Weinmann H (2007) Magnetic resonance imaging of atherosclerosis by targeting extracellular matrix deposition with Gadofluorine M, Contrast Media & Molecular Imaging, 10.1002/cmmi.137, 2:3, (120-129), Online publication date: 1-May-2007. Boudík F, Reissigová J, Hrach K, Tomečková M, Bultas J, Anger Z, Aschermann M and Zvárová J (2006) Primary prevention of coronary artery disease among middle aged men in Prague: Twenty-year follow-up results, Atherosclerosis, 10.1016/j.atherosclerosis.2005.02.011, 184:1, (86-93), Online publication date: 1-Jan-2006. Miranda P, DeFronzo R, Califf R and Guyton J (2005) Metabolic syndrome: Evaluation of pathological and therapeutic outcomes, American Heart Journal, 10.1016/j.ahj.2004.07.012, 149:1, (20-32), Online publication date: 1-Jan-2005. Eigenbrodt M, Bursac Z, Eigenbrodt E, Couper D, Tracy R and Mehta J (2004) Mathematical estimation of the potential effect of vascular remodelling/dilatation on B-mode ultrasound intima-medial thickness, QJM, 10.1093/qjmed/hch120, 97:11, (729-737), Online publication date: 1-Nov-2004. September 10, 2002Vol 106, Issue 11 Advertisement Article InformationMetrics https://doi.org/10.1161/01.CIR.0000030315.80547.3FPMID: 12221043 Originally publishedSeptember 10, 2002 KeywordsatherosclerosistrialsEditorialsmagnetic resonance imagingPDF download Advertisement
Referência(s)