Reduced and oxidized forms of glutathione and α-tocopherol in the cerebrospinal fluid of parkinsonian patients: comparison between before and after l-dopa treatment
1995; Elsevier BV; Volume: 184; Issue: 1 Linguagem: Inglês
10.1016/0304-3940(94)11158-f
ISSN1872-7972
AutoresHideo Tohgi, Takashi Abe, Mika Saheki, Fumitoshi Hamato, Kazuhiro Sasaki, Satoshi Takahashi,
Tópico(s)Antioxidant Activity and Oxidative Stress
ResumoIn the cerebrospinal fluid of untreated patients with Parkinson's disease (PD) the concentrations of reduced glutathione (GSH) and α-tocopherol (α-TOH) were unaltered but the concentration of oxidized glutathione (glutathione disulfide, GSSG) (P < 0.001), the GSSG/GSH ratio (P < 0.06), α-tocopherol quinone (α-TQ) (P < 0.001), and the α-TQ/αa-TOH ratio (P < 0.01) were reduced significantly. In l-dopa-treated patients, the concentrations of GSH, GSSG, and the αa-TQ concentration and the αa-TQ/αa-TOH ratio (P < 0.05) increased compared with untreated PD patients. These results suggest that oxidation of GSH and α-TOH is decreased in untreated PD patients, but is activated to a control level or more after l-dopa treatment.
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