Portal de Periódicos da CAPES

Intra-Arterial Thrombolytic Therapy in Peri-Coronary Angiography Ischemic Stroke

2005; Lippincott Williams & Wilkins; Volume: 36; Issue: 5 Linguagem: Inglês

10.1161/01.str.0000162392.44326.ec

1524-4628

Osama O. Zaidat, A Slivka, Yousef Mohammad, Carmelo Graffagnino, Tony P. Smith, David S. Enterline, Greg Christoforidis, Michael J. Alexander, Dennis M.D. Landis, José I. Suárez,

Intracranial Aneurysms: Treatment and Complications

Background— Intra-arterial thrombolysis (IAT) for peri-coronary angiography (CA) stroke may be safe and efficacious. However, IAT may increase the risk of intracranial hemorrhage (ICH). Methods— A retrospective study was performed involving 3 university hospitals. All peri-CA IAT-treated cases were identified. Patient demographics, stroke severity, angiographic findings, thrombolytic use, modified Rankin Scale (mRS), ICH, and mortality were determined. Results— A total of 21 patients with post–left CA stroke were treated with IAT (mean age 71.8±12.3 years). Arterial occlusion was found in 14 (66.7%) and 7 (33.3%) of the anterior and posterior circulation, respectively. Mean time-to-therapy was 36±12 minutes from the time the neurological deficit was noted. mRS ≤2 occurred in 10 of 21 (48%) patients. Patients with younger age and shorter time-to-IAT had more complete arterial recanalization and clinical recovery. Symptomatic ICH occurred in 3 (14%) cases, and 4 (19%) patients died. Conclusions— Peri-CA IAT appears to be feasible and safe without increased risk of symptomatic ICH and death when compared with the previously reported IAT literature.