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Total synthesis of curacin A

1996; Elsevier BV; Volume: 37; Issue: 7 Linguagem: Inglês

10.1016/0040-4039(95)02337-2

1873-3581

Michael Z. Hoemann, Konstantinos A. Agrios, Jeffrey Aubé,

Traditional and Medicinal Uses of Annonaceae

Curacin A (1) was synthesized in a convergent manner. The key steps were (1) a Julia coupling to establish the stereochemistry of the C(7–10) diene, (2) a Wittig reaction to establish the stereochemistry of the C(3–4) alkene, and (3) a dehydrative cyclization to form the thiazoline ring system.