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Effect of human immunodeficiency virus-1 protease inhibitors on the clearance of human herpesvirus 8 from blood of human Immunodeficiency virus-1-infected patients
2000; Wiley; Volume: 62; Issue: 4 Linguagem: Inglês
10.1002/1096-9071(200012)62
ISSN1096-9071
AutoresJair Carneiro Leão, N. Kumar, Ken McLean, Stephen Porter, Crispian Scully, A V Swan, Chong‐Gee Teo,
Tópico(s)HIV/AIDS drug development and treatment
ResumoJournal of Medical VirologyVolume 62, Issue 4 p. 416-420 Effect of human immunodeficiency virus-1 protease inhibitors on the clearance of human herpesvirus 8 from blood of human Immunodeficiency virus-1-infected patients J.C. Leao, J.C. Leao Departamento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Brazil Oral Medicine Department, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, United Kingdom Hepatitis and Retrovirus Laboratory, PHLS Central Public Health Laboratory, London, United KingdomSearch for more papers by this authorN. Kumar, N. Kumar Oral Medicine Department, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, United Kingdom Hepatitis and Retrovirus Laboratory, PHLS Central Public Health Laboratory, London, United KingdomSearch for more papers by this authorK.A. McLean, K.A. McLean Department of Genitourinary Medicine, Charing Cross Hospital, London UKSearch for more papers by this authorS.R. Porter, S.R. Porter Oral Medicine Department, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, United KingdomSearch for more papers by this authorC.M. Scully, C.M. Scully Oral Medicine Department, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, United KingdomSearch for more papers by this authorA.V. Swan, A.V. Swan PHLS Statistics Unit, London, United KingdomSearch for more papers by this authorC.G. Teo, Corresponding Author C.G. Teo cgteo@phls.nhs.uk Hepatitis and Retrovirus Laboratory, PHLS Central Public Health Laboratory, London, United KingdomHepatitis and Retrovirus Laboratory, PHLS Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, United Kingdom===Search for more papers by this author J.C. Leao, J.C. Leao Departamento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Brazil Oral Medicine Department, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, United Kingdom Hepatitis and Retrovirus Laboratory, PHLS Central Public Health Laboratory, London, United KingdomSearch for more papers by this authorN. Kumar, N. Kumar Oral Medicine Department, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, United Kingdom Hepatitis and Retrovirus Laboratory, PHLS Central Public Health Laboratory, London, United KingdomSearch for more papers by this authorK.A. McLean, K.A. McLean Department of Genitourinary Medicine, Charing Cross Hospital, London UKSearch for more papers by this authorS.R. Porter, S.R. Porter Oral Medicine Department, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, United KingdomSearch for more papers by this authorC.M. Scully, C.M. Scully Oral Medicine Department, Eastman Dental Institute for Oral Health Care Sciences, University of London, London, United KingdomSearch for more papers by this authorA.V. Swan, A.V. Swan PHLS Statistics Unit, London, United KingdomSearch for more papers by this authorC.G. Teo, Corresponding Author C.G. Teo cgteo@phls.nhs.uk Hepatitis and Retrovirus Laboratory, PHLS Central Public Health Laboratory, London, United KingdomHepatitis and Retrovirus Laboratory, PHLS Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, United Kingdom===Search for more papers by this author First published: 07 November 2000 https://doi.org/10.1002/1096-9071(200012)62:4 3.0.CO;2-ZCitations: 22AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The effect of human immunodeficiency virus-1 protease inhibitors on the frequency of human herpesvirus 8 DNA detection from peripheral blood of human immunodeficiency virus-positive persons was evaluated. Thirty-three human immunodeficiency virus-seropositive male patients were studied longitudinally. DNA from open reading frame 26 of the human herpesvirus 8 genome was amplified by the polymerase chain reaction from the CD45+ fraction of peripheral blood before and after the introduction of protease inhibitor therapy. Human herpesvirus 8 IgG status, CD4+ cell counts, and human immunodeficiency virus-1 plasma viral load were also assessed before and after therapy. When both reverse transcriptase inhibitor and protease inhibitor treatment were introduced at the same time, there was an increase in CD4+ T cell counts (P=0.0041), a decrease in human immunodeficiency virus plasma load (P=0.0584), and a decrease in the detection rate of human herpesvirus 8 DNA (P=0.0077). Introducing protease inhibitor to patients already receiving reverse transcriptase inhibitor treatment was associated with an increase in CD4+ T cell counts (P=0.0003), a decrease in human immunodeficiency virus plasma viral load (P=0.0911), and a decrease in the human herpesvirus 8 detection rate (P=0.0412). No significant changes in the titters of anti-human herpesvirus 8 IgG were observed. Treatment with human immunodeficiency virus-1 protease inhibitors is therefore associated with the clearance of human herpesvirus 8 DNA from peripheral blood of human immunodeficiency virus-infected patients. The concomitant decrease in the human immunodeficiency virus plasma load and increase in the peripheral CD4+ cell count suggest that an amelioration in the immune defect following reduction in the burden of human immunodeficiency virus-1 infection is responsible for the clearance of human herpesvirus 8 by protease inhibitors. J. Med. Virol. 62:416–420, 2000. © 2000 Wiley-Liss, Inc. Citing Literature Volume62, Issue4December 2000Pages 416-420 RelatedInformation
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