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Associations of HLA-DP Variants with Hepatitis B Virus Infection in Southern and Northern Han Chinese Populations: A Multicenter Case-Control Study

2011; Public Library of Science; Volume: 6; Issue: 8 Linguagem: Inglês

10.1371/journal.pone.0024221

1932-6203

Jin Li, Da-guo Yang, Yongwen He, Mengyi Wang, Zirong Wen, Lifeng Liu, Jinjian Yao, Koichi Matsuda, Yusuke Nakamura, Jinling Yu, Xiaorui Jiang, Shuzhen Sun, Qing Liu, Xiang Jiang, Qilong Song, Man Chen, Yang Hong, Feng Tang, Zhongyi Hu, Jing Wang, Ying Chang, Xingxing He, Yuan Chen, Ju‐Sheng Lin,

HIV Research and Treatment

Background Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed to examine whether the association can be replicated in Han Chinese populations. Methodology/Principal Findings Two HLA-DP variants rs2395309 and rs9277535 (the most strongly associated SNPs from each HLA-DP locus) were genotyped in three independent Han cohorts consisting of 2 805 cases and 1 796 controls. By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10−8 at rs2395309; P = 8.37×10−3∼2.68×10−10 at rs9277535). In addition, the genotype distributions of both sites (rs2395309 and rs9277535) were clearly different between southern and northern Chinese population (P = 8.95×10−5 at rs2395309; P = 1.64×10−9 at rs9277535). By using asymptomatic HBV carrier as control group, our study showed that there were no associations of two HLA-DP variants with HBV progression (P = 0.305∼0.822 and 0.163∼0.881 in southern Chinese population, respectively; P = 0.097∼0.697 and 0.198∼0.615 in northern Chinese population, respectively). Conclusions Our results confirmed that two SNPs (rs2395309 and rs9277535) in the HLA-DP loci were strongly associated with HBV infection in southern and northern Han Chinese populations, but not with HBV progression.