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DNA Repair: The Importance of Phosphorylating Histone H2AX

2005; Elsevier BV; Volume: 15; Issue: 3 Linguagem: Inglês

10.1016/j.cub.2005.01.029

1879-0445

Noel F. Lowndes, Geraldine W.‐L. Toh,

Cancer-related Molecular Pathways

Abstract How phosphorylated histone H2AX, known as γ-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that γ-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together.