Nifedipine in Biliary and Renal Colic
1987; American Medical Association; Volume: 258; Issue: 24 Linguagem: Inglês
10.1001/jama.1987.03400240048019
ISSN1538-3598
AutoresM. Bortolotti, G. Trisolino, L Barbara,
Tópico(s)Gallbladder and Bile Duct Disorders
ResumoTo the Editor.— Anticholinergics are commonly used in the treatment of biliary and renal colic because of their spasmolytic effect, but when they fail to relieve pain or produce undesirable side effects the only alternatives are morphine and related narcotic-analgesics. However, some calcium antagonists, such as nifedipine, show spasmolytic activity on smooth-muscle cells. 1 This action is utilized in the treatment of cardiovascular diseases where there is arteriolar spasm 2 and in the treatment of some diseases of the gut where spasm is pathogenetically important. 3 Study.— We carried out a preliminary study on the spasmolytic effect of nifedipine in biliary and renal colic whencompared with one of the most commonly used anticholinergics, scopolamine butylbromide (Buscopan). The study was carried out randomly on a total of 32 patients, 16 with biliary colic and 16 with renal colic, admitted consecutively to the University Hospital of Bologna. Patients who had received
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