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FATTY ACID SYNTHETASE OF BRAIN: DEVELOPMENT, INFLUENCE OF NUTRITIONAL AND HORMONAL FACTORS AND COMPARISON WITH LIVER ENZYME

1972; Wiley; Volume: 19; Issue: 3 Linguagem: Inglês

10.1111/j.1471-4159.1972.tb01389.x

1471-4159

Joseph J. Volpe, Yasuo Kishimoto,

Ion Transport and Channel Regulation

Abstract— The activity of fatty acid synthetase was studied in the brain and liver of the developing rat. Synthetase activity in brain was considerably higher in foetal and suckling rats than in older animals However, except for a small transient rise in the perinatal period, activity in liver was low until weaning when a dramatic rise occurred. Activity in brain varied according to the quantity of dietary fat only in long‐term experiments, whereas in liver nutritional influences clearly predominated in determining the rapid developmental changes of synthetase activity. Administration of hydrocortisone diminished hepatic activity but did not change brain synthetase. In the hypothyroid state activity in brain and liver was consistently decreased. However, in the hyperthyroid state hepatic activity increased but activity in brain did not change. The relatively high activity of fatty acid synthetase during brain development has been discussed in relation to the critical role of this enzyme system in brain metabolism. The effect of the hypothyroid state on the activity of brain synthetase suggests the possibility of hormonal control of this enzyme activity. The responses of hepatic synthetase to the hormonal influences delineate a specific step by which these compounds may exert their effect on fatty acid biosynthesis.