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BIBTEX RIS

CUL4B ubiquitin ligase in mouse development: A model for human X-linked mental retardation syndrome?

2012; Springer Nature; Volume: 22; Issue: 8 Linguagem: Inglês

10.1038/cr.2012.79

ISSN

1748-7838

Autores

Yongchao Zhao, Yi Sun,

Tópico(s)

Epigenetics and DNA Methylation

Resumo

CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.

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