A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins
2014; Wiley; Volume: 53; Issue: 52 Linguagem: Inglês
10.1002/anie.201408929
ISSN1521-3773
AutoresBo Qu, Lalith P. Samankumara, Shengli Ma, Keith R. Fandrick, Jean‐Nicolas Desrosiers, Sonia Rodrı́guez, Zhibin Li, Nizar Haddad, Zhengxu S. Han, Keith McKellop, Scott Pennino, Nelu Grinberg, Nina C. Gonnella, Jinhua J. Song, Chris H. Senanayake,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoAbstract Air‐stable P‐chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium‐catalyzed asymmetric hydrogenation of unfunctionalized 1‐aryl‐3,4‐dihydronaphthalenes under one atmosphere pressure of H 2 , up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1‐tetralones.
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