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Microbiota is essential for social development in the mouse

2013; Springer Nature; Volume: 19; Issue: 2 Linguagem: Inglês

10.1038/mp.2013.65

1476-5578

Lieve Desbonnet, Gerard Clarke, Fergus Shanahan, Timothy G. Dinan, John F. Cryan,

Infant Health and Development

limbic afferents. 7 Furthermore, experiences of DBS in man also suggest a persisting modulation of synaptic plasticity, 2 as indicated by a lasting abstinence-sustaining effect of NAcc DBS even after explantation of the stimulation device.On the basis of these findings, we hypothesize that NAcc DBS facilitates heroin and methadone abstinence by promoting neuroplastic changes in dopaminergic neurons.It remains unclear whether the observed beneficial effects allow a generalization to other forms of substance addictions.However, the fact that the patients' comorbid drug consumption did not decline challenges this view.The interpretation of this circumstance in terms of a cross addiction, developing because heroin is no longer available, is also unlikely as the patients did not report increased craving for other psychotropic substances.From a socio behavioral perspective, the application of DBS could have initially led to a heightened motivation to abstain from drugs.However, the disappointing awareness of persisting private and occupational strains in combination with lacking alternative problem solving strategies might account for the ongoing comorbid drug consume.Patient 2 for example, reported to consume amphetamines mainly to keep her weight in balance.Remaining psychosocial difficulties might likewise explain the renewed decrease of self-perceived quality of life (Modular System for Quality of Life (MSQoL) in patient 2, thereby underlining the importance of psychotherapy accompanying DBS in mental disorders to foster the acquisition of alternative behavioral strategies. 8 Although the achieved abstinence from heroin in our patients is highly promising, clinical studies with larger samples (as the clinical trial that is to follow) are needed to further support our hypothesis, and to evaluate accumbal DBS as a cost effective treatment option 9 for otherwise treatment resistant drug addiction.Herein, emphasis must be placed on the patients' pattern of comorbid drug consumption.