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Dexamethasone Reverses Adrenalectomy‐Induced Neuronal De‐differentiation in Midbrain Raphe‐Hippocampus Axisa

1994; Wiley; Volume: 746; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1994.tb39232.x

1749-6632

Efrain C. Azmitia, Baolang Liao,

Neurogenesis and neuroplasticity mechanisms

Annals of the New York Academy of SciencesVolume 746, Issue 1 p. 180-193 Dexamethasone Reverses Adrenalectomy-Induced Neuronal De-differentiation in Midbrain Raphe-Hippocampus Axisa EFRAIN C. AZMITIA, EFRAIN C. AZMITIA Department of Biology New York University 1009 Main Building 100 Washington Square East New York, New York 10003Search for more papers by this authorBAOLANG LIAO, BAOLANG LIAO Department of Biology New York University 1009 Main Building 100 Washington Square East New York, New York 10003Search for more papers by this author EFRAIN C. AZMITIA, EFRAIN C. AZMITIA Department of Biology New York University 1009 Main Building 100 Washington Square East New York, New York 10003Search for more papers by this authorBAOLANG LIAO, BAOLANG LIAO Department of Biology New York University 1009 Main Building 100 Washington Square East New York, New York 10003Search for more papers by this author First published: November 1994 https://doi.org/10.1111/j.1749-6632.1994.tb39232.xCitations: 15 a Support for this work was provided by the National Institute of Aging Program Project AG10108. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Jacobson, M. 1991 Developmental Neurobiology. Third edit. Plenum Press. New York and London . 10.1007/978-1-4757-4954-0 Google Scholar 2 Beach, F. A. 1975. Hormonal modification of sexually dimorphic behavior. Psychoneuroendocrinology. 1: 3–23. Web of Science®Google Scholar 3 Bohn, M. C. 1980. Granule cell genesis in the hippocampus of rats treated neonatally with hydrocortisone. Neuroscience. 5: 2003–2012. CASPubMedWeb of Science®Google Scholar 4 Bohn, M. C. 1984. Glucocorticoid induced teratologies of the nervous system. In Neurobehavioral Teratology. J. Yanai, Ed. 365–387. Elsevier. Amsterdam . Google Scholar 5 Meaney, M., D. Aitken, S. Bhatnagar, C. van Berkel & R. Sapolsky 1988. Post-natal handling attenuates neuroendocrine, anatomical and cognitive impairments related to the aged hippocampus. Science. 238: 766–768. Google Scholar 6 Reddi, A. H. 1982. Local and systemic mechanisms regulating bone formation and remodeling: an overview. In Current Advances in Skeletogenesis: Development, Biomineralization, Mediators, and Metabolic Bone Disease. H. C. Slavkin, Eds. 77–86. Experta Medica. Amsterdam . Google Scholar 7 Lauder, J. M. & F. E. Bloom 1974. Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. J. Comp. Neurol. 155: 469–482. 10.1002/cne.901550407 CASPubMedWeb of Science®Google Scholar 8 Lidov, H. G. W. & M. E. Molliver 1982. Immunohistochemical study of the development of serotonergic neurons in the rat CNS. Brain Res. Bull. 9: 559–604. 10.1016/0361-9230(82)90164-2 CASPubMedWeb of Science®Google Scholar 9 Wallace, J. A. & J. M. Lauder 1983. Development of the serotonergic system in the rat embryo: an immunocytochemical study. Brain Res. Bull. 10: 459–479. CASPubMedWeb of Science®Google Scholar 10 Lidov, H. G. W. & M. E. Molliver 1982. An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields. Brain Res. Bull. 8: 389–430. CASPubMedWeb of Science®Google Scholar 11 Azmitia, E. C., M. J. Brennan & D. Quartermain 1983 Adult development of the hippocampal-serotonin system of C57BL/6N mice; analysis of high-affinity uptake of 3H-5HT. Intl. J. Neurochem. 5: 39–44. 10.1016/0197-0186(83)90006-2 CASPubMedWeb of Science®Google Scholar 12 Azmitia, E. C., M. J. Perlow, M. J. Brennan & J. M. Lauder 1981. Fetal raphe and hippocampal transplants into adult and aged C57BL/6N mice: a preliminary immunocytochemical study. Brain Res. Bull. 7: 703–710. CASPubMedWeb of Science®Google Scholar 13 Azmitia, E. C., B. Liao & Y.-S. Chen 1993. Increase of tryptophan hydroxylase enzyme protein by dexamethasone in adrenalectomized rat midbrain. J. Neurosci. 13: 5041–5055. CASPubMedWeb of Science®Google Scholar 14 Härfstrand, A., K. Fuxe, A. Cintra, L. F. Agnati, I. Zini, A.-C. Wikstrom, S. Okret, Z.-Y. Yu, M. Goldstein, H. Steinbusch, A. Verhofstad & J.-A. Gustafsson 1986. Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain. Proc. Natl. Acad. Sci. USA. 83: 9779–9783. 10.1073/pnas.83.24.9779 PubMedWeb of Science®Google Scholar 15 Alves, S. E. 1994 Neonatal ACTH administration alters the hypothalamic-pituitarygonadal (HPG) and adrenal (HPA) aves in female rats: evidence from monoamine innervation reproductive parameters and the stress response. Ph.D. dissertation. New York University. Google Scholar 16 Sze, P. Y. 1980. Glucocorticoids as a regulatory factor for brain tryptophan hydroxylase during development. Dev. Neurosci. 3: 217–223. CASPubMedWeb of Science®Google Scholar 17 Azmitia, E. C. & B. S. McEwen 1969. Corticosterone regulation of tryptophan hydroxylase in midbrain of the rat. Science. 166: 1274–1276. CASPubMedGoogle Scholar 18 Azmitia, E. C., S. Algeri & E. Costa 1970 In vitro conversion of 3H-L-tryptophan into 3H-serotonin in brain areas of adrenalectomized rats. Science 169: 201–203. 10.1126/science.169.3941.201 CASPubMedWeb of Science®Google Scholar 19 Boadle-Biber, M. C., K. C. Corley, L. Graves, T. Phan & J. Rosecrans 1989. Increase in the activity of tryptophan hydroxylase from cortex and midbrain of male Fischer 344 rats in response to acute or repeated sound stress. Brain Res. 482: 306–316. 10.1016/0006-8993(89)91193-1 CASPubMedWeb of Science®Google Scholar 20 de Kloet, E. R., G. L. Kovacs, G. Szabo, G. Telegdy, B. Bohus & D. H. G. Versteeg 1982. Decreased serotonin turnover in the dorsal hippocampus of rat brain shortly after adrenalectomy: selective normalization after corticosterone substitution. Brain Res. 239: 659–663. 10.1016/0006-8993(82)90546-7 CASPubMedWeb of Science®Google Scholar 21 Singh, V. B., K. C. Corley, H. Phan & M. C. Boadle-Biber 1990. Increases in the activity of tryptophan hydroxylase from rat cortex and midbrain in response to acute or repeated sound stress are blocked by adrenalectomy and restored by dexamethasone treatment. Brain Res. 516: 66–76. 10.1016/0006-8993(90)90898-L CASPubMedWeb of Science®Google Scholar 22 Azmitia, E. C. & B. S. McEwen 1974. Adrenalcortical influence on rat brain tryptophan hydroxylase activity. Brain Res. 78: 291–302. 10.1016/0006-8993(74)90553-8 CASPubMedGoogle Scholar 23 Altman, J. & S. A. Bayer 1975. Postnatal development of the hippocampal dentate gyrus under normal and experimental conditions. In The Hippocampus. K. H. Pribram, Eds.. Vol. 1: 95–122.Plenum Press. New York . 10.1007/978-1-4684-2976-3_5 Google Scholar 24 Altman, J. & S. A. Bayer 1990. Migration and distribution of two populations of hippocampal granule cells precursors during the perinatal and postnatal periods. J. Comp. Neurol. 301: 365–381. 10.1002/cne.903010304 PubMedWeb of Science®Google Scholar 25 Liao, B., B. Mieska & E. C. Azmitia 1993 Loss of 5-HT1A receptor mRNA in the dentate gyrus of long-term adrenalectomized rats and rapid reversal by dexamethasone. Mol. Brain Res. In press. 10.1016/0169-328X(93)90134-B Web of Science®Google Scholar 26 Aronsson, M., K. Fuxe, Y. Dong, L. F. Agnati, S. Okret & J. A. Gustafsson 1988 Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization. Proc. Natl. Acad. Sci. USA 85: 9331–9335. 10.1073/pnas.85.23.9331 CASPubMedWeb of Science®Google Scholar 27 Isaacson, R. L. & K. H. Pribram 1975 The Hippocampus. Vol. 2. Neurophysiology and Behavior Plenum Press. New York & London . 10.1007/978-1-4684-2976-3 Google Scholar 28 Chan-Palay, V. & C. Kohler 1989 The Hippocampus: New Vistas. Alan R. Liss, Inc. New York . Google Scholar 29 Lynch, G., G. Rose, C. Gall & C. W. Cotman 1973. The response of the dentate gyrus to partial deafferentation. In The Golgi Centennial Symposium. R. Santini, Ed. Raven Press. New York . Google Scholar 30 Bohn, M. C. 1979 Effects of hydrocortisone on neurogenesis in the neonatal rat brain: a morphological and autoradiographic study. Ph.D. dissertation. University of Connecticut at Storrs. Google Scholar 31 Woolley, C. S., E. Gould, R. R. Sakai, R. L. Spencer & B. S. McEwen 1991. Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat. Brain Res. 554: 312–315. 10.1016/0006-8993(91)90207-C CASPubMedWeb of Science®Google Scholar 32 Gould, H., C. S. Woolley & B. S. McEwen 1990. Short-term glucocorticoid manipulations affect neuronal morphology and survival in the adult dentate gyrus. Neuroscience. 37: 367–375. PubMedWeb of Science®Google Scholar 33 Sloviter, R. S., G. Valiquette, G. M. Abrams, E. C. Ronk, A. L. Sollas, L. A. Paul & S. Neubort 1989. Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy. Science. 243: 535–538. PubMedWeb of Science®Google Scholar 34 Sloviter, R. S., E. Dean & S. Neubort 1993. Electron microscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat: apoptosis in adult central nervous system. J. Comp. Neurol. 330: 337–351. 10.1002/cne.903300305 PubMedWeb of Science®Google Scholar 35 Meyer, J. S. 1985. Biochemical effects of the corticosteroids on neural tissues. Physiol. Rev. 65: 946–1020. CASPubMedWeb of Science®Google Scholar 36 Dahl, D., D. C. Rueger, A. Bignami, K. Weber & M. Osborn 1981. Vimentin, the 57000 molecular weight protein of fibroblast filaments, is the major cytoskeletal component in immature glia. Eur. J. Cell Biol. 24: 191–196. CASPubMedWeb of Science®Google Scholar 37 Hellendall, R. P., U. Schambra, J. Liu, G. R. Bresse, D. E. Millhorn & J. Lauder 1992. Detection of serotonin receptor transcripts in the developing nervous system. J. Chem. Neuroant. 5: 279–310. Google Scholar 38 Whitaker-Azmitia, P. M., R. Murphy & E. C. Azmitia 1990 Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology. Brain Res. 528: 155–158. 10.1016/0006-8993(90)90210-3 CASPubMedWeb of Science®Google Scholar 39 Azmitia, E. C., W. S. T. Griffin, D. R. Marshak, L. J. van Eldik & P. M. Whitaker-Azmitia 1992. S-100β and serotonin: a possible astrocytic-neuronal link to neuropathology of Alzheimer's disease. Prog. Brain Res. 94: 459–473. 10.1016/S0079-6123(08)61773-2 CASPubMedWeb of Science®Google Scholar 40 Akbari, H. M., P. M. Whitaker-Azmitia & E. C. Azmitia 1994 In utero exposure to cocaine results in decreased availability of the tropic factor S-100β: a possible mechanism for cocaine-induced microcephaly. Neurosci. Lett. 170: 141–144. 10.1016/0304-3940(94)90259-3 CASPubMedWeb of Science®Google Scholar 41 Daugherty, J. A. & J. H. Haring 1989. Effects of neonatal serotonin depletion upon development of rat somatosensory cortex. Soc. Neurosci. Abstr. 15: 1050. Google Scholar 42 Okado, N., L. Cheng, S. Tanatsugu & K. Hamaguchi 1993. Synaptic loss following removal of serotonergic fibers in newly hatched and adult chickens. J. Neurobiol. 24: 687–691. 10.1002/neu.480240512 CASPubMedWeb of Science®Google Scholar 43 Azmitia, E. C. & P. M. Whitaker-Azmitia 1991. Awaking the sleeping giant: anatomy and plasticity of the brain serotonergic system. J. Clin. Psychiatry. 52: 4–16. PubMedWeb of Science®Google Scholar 44 Whitaker-Azmitia, P. M., C. Clarke & E. C. Azmitia 1993 Localization of 5-HT1A receptors to astroglial cells in adult rats: implication for neuronal-glial interactions and psychoactive drug mechanism of action. Synapse 14: 201–205. 10.1002/syn.890140303 CASPubMedWeb of Science®Google Scholar 45 Azmitia, E. C., D. R. Marshak & P. M. Whitaker-Azmitia 1990. Functional interactions between glial S-100β and CNS 5-HT neurons. J. Cell Biochem. 8: 14F. Google Scholar 46 Haring, J. H., A. Hagan, J. Olson & B. Rodgers 1993. Hippocampal serotonin levels influence the expression of S-100β detected by immunocytochemistry. Brain Res. 631: 119–123. 10.1016/0006-8993(93)91195-X CASPubMedWeb of Science®Google Scholar 47 Whitaker-Azmitia, P. M., A. Borella, N. Raio, N. Okado & E. C. Azmitia 1994. Serotonin as a synapse maintenance factor in the adult hippocampus: loss of synaptic markers after PCPA treatment. Soc. Neurosci. Abstr. 20: 200. Google Scholar 48 Hagg, T., B. Fass-Holmes, H. L. Vahlsing, M. Manthrope, J. M. Conner & S. Varon 1989. Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neurons. Brain Res. 505: 29–38. 10.1016/0006-8993(89)90112-1 CASPubMedWeb of Science®Google Scholar 49 Maehlen, J. & A. Torvik 1990. Necrosis of granule cells of hippocampus in adrenalcortical failure. Acta Neuropathol. 80: 85–87. PubMedWeb of Science®Google Scholar 50 Liao, B. & E. C. Azmitia 1994. Differential effects of corticosteroids on neuronal and glial cells in the dentate gyrus of adult rat hippocampus. Soc. Neurosci. Abstr. 20: 600. Google Scholar 51 Popov, V. I., L. S. Bocharova & A. G. Bragen 1992. Repeated changes of dendritic morphology in the hippocampus of ground squirrels in the course of hibernation. Neuroscience. 48: 45–51. CASPubMedWeb of Science®Google Scholar 52 Azmitia, E. C., J. Huang & P. M. Whitaker-Azmitia. Steroid interactions with serotonin as a synaptic maintenance factor in adult hippocampus: reversal of synaptic loss by dexamethasone. Soc. Neurosci. Abstr. 20: 200. Google Scholar 53 Azmitia, E. C. 1973 Rapid alterations in rat tryptophan hydoxylase activity: effects of adrenal steroids, drugs and stressors. Ph.D. dissertation. The Rockefeller University. New York . Google Scholar Citing Literature Volume746, Issue1Brain Corticosteroid Receptors: Studies on the Mechanism, Function, and Neurotoxicity of Corticosteroid ActionNovember 1994Pages 180-193 ReferencesRelatedInformation