Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Trypanocidal activity of lipophilic diamines and amino alcohols

2010; Elsevier BV; Volume: 64; Issue: 9 Linguagem: Inglês

10.1016/j.biopha.2010.06.002

1950-6007

Celso de Oliveira Rezende Júnior, Rosana O. Alves, Carlos A. Rezende, Cristiane França da Costa, Heveline Silva, Mireille Le Hyaric, Adriana Fontes, Ricardo José Alves, Álvaro J. Romanha, M.V. De Almeida,

Insect and Pesticide Research

Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth. The most active ones were compounds 3, 4 and 5 with a IC₅₀ of 31.2 μg/mL, activity similar to the reference drug crystal violet.