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Going the Distance: A Current View of Enhancer Action

1998; American Association for the Advancement of Science; Volume: 281; Issue: 5373 Linguagem: Inglês

10.1126/science.281.5373.60

1095-9203

Elizabeth M. Blackwood, James T. Kadonaga,

RNA and protein synthesis mechanisms

In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional enhancers are discrete DNA elements that contain specific sequence motifs with which DNA-binding proteins interact and transmit molecular signals to genes. Here, current models regarding the role of enhancers in the regulation of transcription by RNA polymerase II are presented.