Portal de Periódicos da CAPES

Pig Ear Skin as an In-vitro Model for Human Skin Permeability

1992; Oxford University Press; Volume: 44; Issue: 8 Linguagem: Inglês

10.1111/j.2042-7158.1992.tb05485.x

2042-7158

Ian P Dick, Robert C. Scott,

Plant Surface Properties and Treatments

Abstract Pig skin has been shown to have similar histological and physiological properties to human skin and has been suggested as a good model for human skin permeability. In this series of experiments, the in-vitro permeability of pig ear skin was compared with human (abdominal) skin and rat (dorsal) skin using both hydrophilic (water, mannitol, paraquat) and lipophilic (aldrin, carbaryl, fluazifop-butyl) penetrants. Pig skin was found to have a closer permeability character than rat skin to human skin, particularly for lipophilic penetrants. Electrical conductivity measurements across pig skin membranes showed that skin conductivity could be a useful method for assessing the integrity of membranes, particularly when used in conjunction with water permeability assessments.