Synthesis and structure–activity relationships of 1-Phenylpyrazoles as xanthine oxidase inhibitors
2001; Elsevier BV; Volume: 11; Issue: 7 Linguagem: Inglês
10.1016/s0960-894x(01)00093-2
ISSN1464-3405
AutoresSeigo Ishibuchi, Hiroshi Morimoto, Takanori Oe, Tsuguo Ikebe, Hiroyoshi Inoue, Atsushi Fukunari, Miho Kamezawa, I. Yamada, Yoichi Naka,
Tópico(s)Eosinophilic Disorders and Syndromes
ResumoA series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.
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