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Sample conditions determine the ability of thrombin generation parameters to identify bleeding phenotype in FXI deficiency

2015; Elsevier BV; Volume: 126; Issue: 3 Linguagem: Inglês

10.1182/blood-2014-12-616565

1528-0020

G. N. Pike, A. M. Cumming, C. R. M. Hay, Paula Bolton‐Maggs, John Burthem,

Platelet Disorders and Treatments

Key Points When contact activation is inhibited, Factor XI:C levels only correlate with thrombin generation if platelets are present. Thrombin generation measured in platelet-rich plasma with contact activation inhibition identifies bleeding phenotype in FXI deficiency.