Hyperphagia and obesity in rats with bilateral ibotenic acid-induced lesions of the ventromedial hypothalamic nucleus
1987; Elsevier BV; Volume: 416; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(87)91508-3
ISSN1872-6240
AutoresNobuaki Shimizu, Yutaka Oomura, Carlos R. Plata‐Saláman, Masatoshi Morimoto,
Tópico(s)Sleep and Wakefulness Research
ResumoMacro-electrophoretic applications of the cellular neurotoxin ibotenic acid into the ventromedial hypothalamic nucleus (VMH) resulted in hyperphagia and obesity in male rats. Histological examination showed a reduction in the number of neuronal VMH cell bodies with glial proliferation without evidence of non-specific damage. This supports the hypothesis that hyperphagia and obesity after VMH lesions are related to destruction of neurons intrinsic to the VMH.
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