Portal de Periódicos da CAPES

Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

2010; Nature Portfolio; Volume: 42; Issue: 8 Linguagem: Inglês

10.1038/ng.626

1546-1718

Lucía Conde, Eran Halperin, Nicholas K. Akers, Kevin M. Brown, Karin E. Smedby, Nathaniel Rothman, Alexandra Nieters, Susan L Slager, Angela Brooks‐Wilson, Luz Agana, Jacques Riby, Jianjun Liu, Hans‐Olov Adami, Hatef Darabi, Henrik Hjalgrim, Hui-Qi Low, Keith Humphreys, Mads Melbye, Ellen T. Chang, Bengt Glimelius, Wendy Cozen, S. Scott Davis, Patricia Hartge, Lindsay M. Morton, Maryjean Schenk, Sophia Wang, Bruce K. Armstrong, Anne Kricker, Sam Milliken, Mark P. Purdue, Claire M. Vajdic, Peter Boyle, Qing Lan, Shelia Hoar Zahm, Yawei Zhang, Tongzhang Zheng, Nikolaus Becker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Katja Butterbach, Pierluigi Cocco, Lenka Foretová, Marc Maynadié, Sílvia de Sanjosé, Anthony Staines, John J. Spinelli, Sara J. Achenbach, Timothy G. Call, Nicola J. Camp, Martha Glenn, Neil E. Caporaso, James R. Cerhan, Julie M. Cunningham, Lynn R. Goldin, Curtis A. Hanson, Neil E. Kay, Mark C. Lanasa, José F. Leis, Gerald E. Marti, Kari G. Rabe, Laura Z. Rassenti, Logan G. Spector, Sara S. Strom, Celine M. Vachon, J. Brice Weinberg, Elizabeth A. Holly, Stephen J. Chanock, Martyn T. Smith, Paige M. Bracci, Christine F. Skibola,

Viral-associated cancers and disorders

Christine Skibola and colleagues identify variants at 6p21.32 associated with risk of follicular lymphoma, providing further support that variation in the MHC region influences risk of this disease. They also replicate previously reported risk variants for chronic lymphocytic leukemia. To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10−29 and rs7755224, combined P = 2.00 × 10−19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10−9).