Determination of mitoxantrone using phase-selective a.c. adsorptive stripping voltammetry in a flow system with selectivity enhancement
1992; Elsevier BV; Volume: 256; Issue: 2 Linguagem: Inglês
10.1016/0003-2670(92)85348-a
ISSN1873-4324
AutoresJuan Carlos Cortina Villar, Agustı́n Costa Garcı́a, Paulino Tuñón Blanco,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoA flow cell incorporating a stationary carbon paste electrode coupled with a.c. voltammetry was used. Preconcentration and determination of the cancer chemotherapy drug mitoxantrone (MXT) were achieved via a flow-injection approach utilizing adsorption of the drug on the electrode, followed by medium exchange and a.c. voltammetry on the adsorbed surface. A linear response was obtained in the concentration range 5 × 10−9–1.5 × 10−7 M with aqueous samples. The method was used for the determination of MXT in urine without any sample pretreatment; the relative standard deviation obtained was 1.1% (n = 5) with a concentration of 1 × 10−6 M. The proposed method is more selective than other methods suggested for the determination of MXT in urine and plasma samples, which usually require some kind of sample pretreatment.
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