Portal de Periódicos da CAPES

Selenium in Bone Health: Roles in Antioxidant Protection and Cell Proliferation

2013; Multidisciplinary Digital Publishing Institute; Volume: 5; Issue: 1 Linguagem: Inglês

10.3390/nu5010097

2072-6643

Huawei Zeng, Jay Cao, Gerald F. Combs,

Heavy Metal Exposure and Toxicity

Selenium (Se) is an essential trace element for humans and animals, and several findings suggest that dietary Se intake may be necessary for bone health. Such findings may relate to roles of Se in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Elucidation of the mechanisms by which Se supports these cellular processes can lead to a better understanding of the role of this nutrient in normal bone metabolism. This article reviews the current knowledge concerning the molecular functions of Se relevant to bone health.