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Insight into the High Duplex Stability of the Simplified Nucleic Acid GNA

2009; Wiley; Volume: 48; Issue: 5 Linguagem: Inglês

10.1002/anie.200803472

1521-3773

Mark K. Schlegel, Xiulan Xie, Lilu Zhang, Eric Meggers,

RNA and protein synthesis mechanisms

A preorganized zipper: The entropic penalty for duplex formation is significantly smaller for the backbone-simplified nucleic acid analogue GNA (glycol nucleic acid) than for DNA. This finding is consistent with a conformational preorganization of the single strands in combination with especially favorable stacking interactions in the corresponding GNA duplex (see picture).