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A new efficient method for the preparation of 99mTc-radiopharmaceuticals containing the TcN multiple bond

1992; Pergamon Press; Volume: 43; Issue: 11 Linguagem: Inglês

10.1016/0883-2889(92)90004-x

1878-1128

Roberto Pasqualini, Veronique Comazzi, E. Bellande, Adriano Duatti, Andrea Marchi,

Inhalation and Respiratory Drug Delivery

An improved method for the preparation of 99mTc-radiopharmaceuticals containing the TcN multiple bond, in sterile and apyrogen conditions, is described. This method is based on the reaction of [99mTc]pertechnetate with ligands derived from S-methyl dithiocarbazate [H2NN(R)C(S)SCH3 [R = H, CH3], in the presence of HCl and tertiary phosphines. It was found that these derivatives can behave both as sources of nitride nitrogen ions (N3−) and as coordinating ligands. The reaction leads to the formation of intermediate technetium-nitrido complexes in high yield. These intermediate species can be used as suitable prereduced substrates for the preparation of technetium-nitrido radiopharmaceuticals through simple substitution reactions with appropriate exchanging ligands.