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Increased incidence of malignancy in dermatitis herpetiformis.

1983; BMJ; Volume: 286; Issue: 6358 Linguagem: Inglês

10.1136/bmj.286.6358.16

0959-8138

J.N. LEONARD, William F. Tucker, John Fry, Carmel Coulter, A W Boylston, R. M. H. McMinn, G P Haffenden, A.F. SWAIN, L. Fry,

Microscopic Colitis

A retrospective study of 109 patients with dermatitis herpetiformis showed that malignant tumours had developed in seven patients, the expected incidence being 2.93, giving a relative risk of 2.38. In three of the seven patients the malignancy was a lymphoma, giving a relative risk of 100 for this tumour (expected incidence 0.03). In six of the seven patients who developed malignancies small-intestinal biopsy specimens were macroscopically abnormal, giving a relative risk of 4.22 in this group, which is similar to that reported in adult coeliac disease. Patients treated with a gluten-free diet appeared to have a reduced risk of developing malignancy compared with those taking a normal diet (relative risk with gluten-free diet 1.01 and with normal diet 3.09). A small subgroup of eight patients with linear IgA dermatitis herpetiformis were also studied: three developed malignant disease and in one the tumour was a lymphoma.