Structure and Mechanism of Lysine-specific Demethylase Enzymes
2007; Elsevier BV; Volume: 282; Issue: 49 Linguagem: Inglês
10.1074/jbc.r700027200
ISSN1083-351X
AutoresRuchi Anand, Ronen Marmorstein,
Tópico(s)Histone Deacetylase Inhibitors Research
ResumoThe discovery of histone-demethylating enzymes has revealed yet another reversible histone modification mark. In this review, we describe the structural and chemical insights that we have now derived underlying the activity of these enzymes. The recent co-crystal structures of LSD1 bound to a proparylamine-derivatized histone H3 peptide and JHDM structures bound to two different methylated histone H3 peptides illustrate the steric requirements and structural basis for substrate specificity.
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