Produção Nacional
Revisado por pares
Efeito da sinvastatina na sepse abdominal de ratos diabéticos
2010; Brazilian College of Surgeons; Volume: 37; Issue: 1 Linguagem: Inglês
10.1590/s0100-69912010000100009
ISSN1809-4546
AutoresIrami Araújo-Filho, Daniel Tôrres Jácome, Amália Cínthia Meneses do Rêgo, Ítalo Medeiros Azevedo, Eryvaldo Sócrates Tabosa do Egito, Aldo Cunha Medeiros,
Tópico(s)Pancreatitis Pathology and Treatment
ResumoInfection and sepsis are major causes of morbidity and mortality after surgery of diabetic patients. Statins have been shown to exhibit anti-inflammatory and immunomodulatory (pleiotropic) effects, independent of lipid lowering. This study aimed to observe whether the pretreatment with simvastatin in a cecal ligation and perforation model of sepsis is beneficial in diabetic rats.Fifty six Wistar rats were randomly assigned to non-diabetic group (n=28), and streptozotocin-induced diabetic group (n=28). Abdominal sepsis was induced in 14 diabetic and in 14 non diabetic rats and the other 28 rats were allocated on sham group. Sepsis rats and sham rats (each with 7 animals) were treated with oral simvastatin (20 mg kg-1 day-1) or normal saline solution 0.9%. Peripheral blood TNFalpha, IL-1beta, IL-6, C-reactive protein, procalcitonin, leukocytes and neutrophils were tested in all the animals. Statistical analysis was done by ANOVA and Tukey test, with p<0.05.Simvastatin reduced mortality in diabetic rats. Peripheral blood TNFalpha, IL-1beta, IL-6, C-reactive protein, procalcitonin, leukocytes and neutrophils were lower in diabetic and non diabetics septic rats treated with simvastatin, than after saline treatment.Simvastatin showed anti-inflammatory effect, which could play some protection against the progress of sepsis in diabetic rats.
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