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Further response of acetylcholinesterase and of conduction in bullfrog sciatic nerve to the stereochemistry of amine inhibitors. II

1959; Elsevier BV; Volume: 83; Issue: 2 Linguagem: Inglês

10.1016/0003-9861(59)90050-5

1096-0384

S.L. Friess, Ernest R. Whitcomb, R.C. Durant, P.A. French,

Botanical Research and Chemistry

The stereochemical responses of acetylcholinesterase and bullfrog sciatic nerve to structural variations in the compound sequence I–III have been compared. The enzyme does not differentiate between configurations at the β-carbon atom in Ib, whereas the nerve shows specificity in terms of reversibility of blockade. Both nerve and enzyme show greater sensitivity to blockade by the cis-isomer III than by the trans-species II.