Catalytic Enantioselective CH Functionalization of Alcohols by Redox-Triggered Carbonyl Addition: Borrowing Hydrogen, Returning Carbon
2014; Wiley; Volume: 53; Issue: 35 Linguagem: Inglês
10.1002/anie.201403873
ISSN1521-3773
AutoresJohn M. Ketcham, Inji Shin, T. Patrick Montgomery, Michael J. Krische,
Tópico(s)Chemical Synthesis and Analysis
ResumoAbstract The use of alcohols and unsaturated reactants for the redox‐triggered generation of nucleophile–electrophile pairs represents a broad, new approach to carbonyl addition chemistry. Discrete redox manipulations that are often required for the generation of carbonyl electrophiles and premetalated carbon‐centered nucleophiles are thus avoided. Based on this concept, a broad, new family of enantioselective CC coupling reactions that are catalyzed by iridium or ruthenium complexes have been developed, which are summarized in this Minireview.
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